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MAP3K14 (NIK) is structurally related to MAP3Ks. MAP3K14 phosphorylates and activates CHUK (IKKalpha) and IKBKB (IKK beta), which in turn phosphorylate IkB-alpha, releasing NF-KappaB leading to up-regulation of inflammatory response genes. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: alymphoplasia; HsNIK; Mitogen-activated protein kinase kinase kinase 14; NF kappa B-inducing kinase; NF-kappa-beta-inducing kinase; Nfkb inducing kinase; protein kinase; Serine/threonine-protein kinase NIK
基因别名: aly; FTDCR1B; HS; HSNIK; MAP3K14; NIK
UniProt ID: (Human) Q99558, (Mouse) Q9WUL6
Entrez Gene ID: (Human) 9020, (Rat) 360640, (Mouse) 53859