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产品信息
PA5-83061
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.05 mg/mL
纯化类型
Anitgen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2790217
产品详细信息
Immunogen sequence: ATVQDMLSSH HYKSFKVSMI HRLRFTTDVQ LGISGDKVEI DPVTNQKAST KFWIKQKPIS IDSDLLCACD LAEEKSPSHA IFKLTYLSNH DYKHLYFESD AATVNEIVLK VNYILESRAS TARADYFAQK QRKLNRRTSF SFQKEKKSGQ
靶标信息
Sin1 was initially identified as the human homolog of S. pombe SIN1. Recent evidence has shown that it identical to Mip1, a protein that interacts with MEKK2, a member of the mitogen-activated protein kinase (MAPK) intracellular signaling network. MAPKAP1 is thought to prevent MEKK2 activation and dimerization by forming a complex with the inactive and non-phosphorylated MEKK2, thereby blocking the JNK1/2, ERK1/2, p38 and ERK5 MAPKs. MAPKAP1 has also been shown to play a role in the TOR signaling process, a pathway that is involved in controlling cell growth and proliferation in response to environmental cues such as nutrients, growth factors and hormones. Experiments showed that MAPKAP1 helped to maintain the TOR/rictor assembly but not the TOR/RAPTOR complex, which allowed specific phosphorylation of Akt, a kinase that is believed to couple the growth factor-PI3K signaling pathway to the nutrient-regulated TOR signaling pathway. Multiple alternatively spliced isoforms of MAPKAP1 have been identified.
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生物信息学
蛋白别名: MEKK2-interacting protein 1; MGC2745; MIP1SIN1SIN1b; Mitogen-activated protein kinase 2-associated protein 1; mSIN1; ras inhibitor MGC2745; RP11-269P11.1; SAPK-interacting protein 1; stress-activated map kinase interacting protein 1; Stress-activated map kinase-interacting protein 1; stress-activated protein kinase-interacting 1; Target of rapamycin complex 2 subunit MAPKAP1; TORC2 subunit MAPKAP1
基因别名: JC310; MAPKAP1; MIP1; SIN1; SIN1b; SIN1g
UniProt ID: (Human) Q9BPZ7
Entrez Gene ID: (Human) 79109
