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产品信息
PA5-56570
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2643757
产品详细信息
Immunogen sequence: EKHSPDSACS VDYSSSCLSS PEHPTEDSES TEPLSVDGIS SDLEEPAEGD EEEEEEEGGM GPYGLQEGSP QTPDQEQFLK QHFETLA
Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 90%.
靶标信息
MAP kinases play a significant role in many biological processes, including cell adhesion and spreading, cell differentiation and apoptosis. MAPKBP-1 (mitogen-activated protein kinase binding protein 1), also known as JNKBP-1, is a 1,514 amino acid protein that contains twelve WD repeats. Induced by TRAF2 (TNF receptor-associated factor 2) and Tak1 (TGF-beta-activated kinase 1), MAPKBP-1 is thought to act an adaptor protein for NFkappaB (nuclear factor kappa-B) activation. MAPKBP-1 interacts with JNK3 and may promote TRAF2 polyubiquitination. MAPKBP-1 exists as six alternatively spliced variants and is encoded by a gene located on human chromosome 15. Human chromosome 15 houses over 700 genes and comprises nearly 3% of the human genome. Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease and Marfan syndrome are all associated with defects in chromosome 15-localized genes.
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生物信息学
蛋白别名: JNK-binding protein 1; JNKBP-1; mitogen activated protein kinase binding protein 1; Mitogen-activated protein kinase-binding protein 1
基因别名: JNKBP-1; JNKBP1; KIAA0596; MAPKBP1
UniProt ID: (Human) O60336
Entrez Gene ID: (Human) 23005
