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MBP Antibody (MA1-24990) in IHC
British journal of cancer 2023 -
Th2 cell administration enhances innate immune cell activity in gastrointestinal cancers. The expression of Mbp , Mpo and Nos2 ( a ) at the mRNA level in PK5L1940 and BRAF cell-derived allograft tumors obtained from Rag1 -/- mice injected with Th2 cells in relation to untreated Rag1 -/- mice are increased. Representative images of immunohistochemistry staining showing that MBP ( b ), MPO ( c ) and NOS2 ( d ... View More
产品信息
MA1-24990
应用
建议稀释比
已发表文章
产品规格
种属反应
Bovine,
Human
已发表种属
Human,
Mouse
宿主/亚型
Rat
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
14
抗原
Synthetic peptide corresponding to residues 36-50 of bovine Myelin Basic Protein.
偶联物
Unconjugated
形式
Liquid
浓度
Conc. not determined
保存液
tissue culture supernatant
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_794984
产品详细信息
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 20 kDa microtubule-stabilizing protein; golli mbp; MBP; MGC99675; microtubule-stabilizing protein; Myelin A1 protein; Myelin basic protein; Myelin membrane encephalitogenic protein
基因别名: MBP
UniProt ID: (Human) P02686
Entrez Gene ID: (Human) 4155, (Bovine) 618684
immune response
chemical synaptic transmission
central nervous system development
aging
axon ensheathment
response to toxic substance
substantia nigra development
response to progesterone
response to tumor necrosis factor
myelination
response to mercury ion
negative regulation of axonogenesis
membrane organization
response to fatty acid
