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产品信息
PA5-43647
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide directed towards the N-terminal of human MDFIC
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2576836
产品详细信息
Peptide sequence: SVRPAGRRAR RQRRGAGSAE RPMSGAGEAL APGPVGPQRV AEAGGGQLGS
Sequence homology: Human: 100%; Rabbit: 92%
靶标信息
MDFIC is a member of a family of proteins characterized by a specific cysteine-rich C-terminal domain, which is involved in transcriptional regulation of viral genome expression. Alternative translation initiation from an upstream non-AUG (GUG), and an in-frame, downstream AUG codon, results in the production of two isoforms, p40 and p32, respectively, which have different subcellular localization; p32 is mainly found in the cytoplasm, whereas p40 is targeted to the nucleolus. Both isoforms have transcriptional regulatory activity that is attributable to the cysteine-rich C-terminal domain.This gene product is a member of a family of proteins characterized by a specific cysteine-rich C-terminal domain, which is involved in transcriptional regulation of viral genome expression. Alternative translation initiation from an upstream non-AUG (GUG), and an in-frame, downstream AUG codon, results in the production of two isoforms, p40 and p32, respectively, which have different subcellular localization; p32 is mainly found in the cytoplasm, whereas p40 is targeted to the nucleolus. Both isoforms have transcriptional regulatory activity that is attributable to the cysteine-rich C-terminal domain.
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生物信息学
蛋白别名: hIC; I-mfa domain-containing protein; MDFIC; MDFIC (HGNC:28870); MyoD family inhibitor domain-containing protein
基因别名: HIC; MDFIC
UniProt ID: (Human) Q9P1T7
Entrez Gene ID: (Human) 29969
transcription, DNA-templated
activation of JUN kinase activity
viral process
regulation of Wnt signaling pathway
negative regulation of protein import into nucleus
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of viral transcription
