Invitrogen

MECP2 Polyclonal Antibody

查看其他27个MECP2抗体

产品信息

PA5-143629

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000

-

免疫组化（石蜡） (IHC (P))

1:100-1:250

-

产品规格

种属反应

Human, Mouse, Non-human primate

宿主/亚型

Chicken / IgY

分类

Polyclonal

类型

Antibody

抗原

Full length human recombinant MeCP2

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

20 mg/mL

纯化类型

IgY fraction

保存液

PBS

内含物

5mM sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2942858

产品详细信息

Specific for endogenous levels of the MeCP2 protein. Due to usually high charge, the protein runs at ~75 kDa in SDS-PAGE of mouse brain lysates.

靶标信息

MECP2 belongs to a family of nuclear proteins (including MBD1, MBD2, MBD3 and MBD4) that have a methyl-CpG binding domain. MECP2 is capable of binding specifically to methylated DNA. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. MECP2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: DKFZp686A24160; MeCp-2 protein; methyl CpG binding protein 2; Methyl-CpG-binding protein 2; testis tissue sperm-binding protein Li 41a

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基因别名: 1500041B07Rik; AUTSX3; D630021H01Rik; Mbd5; MECP2; MRX16; MRX79; MRXS13; MRXSL; PPMX; RS; RTS; RTT; WBP10

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UniProt ID: (Human) P51608, (Mouse) Q9Z2D6

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Entrez Gene ID: (Human) 4204, (Mouse) 17257

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four-way junction DNA binding DNA binding transcription factor activity, sequence-specific DNA binding transcription corepressor activity mRNA binding protein binding transcription factor binding methyl-CpG binding double-stranded methylated DNA binding protein domain specific binding chromatin DNA binding siRNA binding histone deacetylase binding poly(A) RNA binding unmethylated CpG binding protein N-terminus binding chromatin binding enzyme binding DNA metabolism protein

参与通路

negative regulation of transcription from RNA polymerase II promoter behavioral fear response response to hypoxia startle response neurological system process involved in regulation of systemic arterial blood pressure regulation of respiratory gaseous exchange by neurological system process inositol metabolic process mitochondrial electron transport, ubiquinol to cytochrome c chromatin silencing regulation of gene expression by genetic imprinting transcription, DNA-templated glutamine metabolic process cellular biogenic amine metabolic process synapse assembly heart development respiratory gaseous exchange long-term memory locomotory behavior protein localization glucocorticoid metabolic process positive regulation of cell proliferation adult locomotory behavior visual learning response to radiation pathogenesis post-embryonic development response to ionizing radiation response to lead ion dendrite development histone methylation histone acetylation proprioception sensory perception of pain cerebellum development ventricular system development negative regulation of histone methylation cardiolipin metabolic process response to estradiol negative regulation of histone acetylation social behavior neuron maturation negative regulation of neuron apoptotic process regulation of DNA methylation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated phosphatidylcholine metabolic process negative regulation of astrocyte differentiation catecholamine secretion positive regulation of synapse assembly excitatory postsynaptic potential long-term synaptic potentiation regulation of transcription, DNA-templated chemical synaptic transmission brain development learning memory embryo development regulation of gene expression neuron differentiation neuron projection development multicellular organismal response to stress regulation of gene expression, epigenetic regulation of synaptic plasticity neuromuscular process controlling posture neuromuscular process