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Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
In mammalian cells, transcription is regulated in part by high molecular weight co-activating complexes that mediate signals between transcriptional activators and RNA polymerase II (Pol II). The mediator complex is one such multi-protein structure that functions as a bridge between regulatory proteins and Pol II, thereby regulating Pol II-dependent transcription. Med9 (mediator complex subunit 9), also known as MED25, is a 146 amino acid nuclear protein and component of the mediator complex. Med9 directly interacts with Med4 and is encoded by a gene that maps to human chromosome 17p11.2. Chromosome 17 comprises over 2.5% of the human genome, encodes over 1,200 genes and is associated with two key tumor suppressor genes, namely, p53 and BRCA1.
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蛋白别名: Mediator complex subunit 9; Mediator of RNA polymerase II transcription subunit 9; mediator of RNA polymerase II transcription, subunit 9 homolog; mediator subunit 25
基因别名: BC019367; MED25; MED9; RGD1563669
UniProt ID: (Human) Q9NWA0, (Mouse) Q8VCS6
Entrez Gene ID: (Human) 55090, (Mouse) 192191, (Rat) 497914
分子生物学功能: RNA metabolism protein nucleic acid metabolism protein general transcription factor