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产品信息
PA5-52459
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2643868
产品详细信息
Immunogen sequence: KDREQRGQEN TSGFWLNRSN ELIWLELQAW HAGRTINDQD FFLYTARQAI PDIINEILTF KVDYGSFAFV RDRAGFNGTS VEGQCKATPG TKIVGYSTHH EHLQRQRVSF EQVKRIMELL EYIEALYPSL Q
Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 85%.
靶标信息
This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: dJ473J16.1 (mitogen-activated protein kinase kinase kinase 4); JNKK1; MAP three kinase 1; MAP/ERK kinase kinase 4; MAP2K4; MAPK/ERK kinase kinase 4; MEK kinase 4; Mitogen-activated protein kinase kinase kinase 4; predicted protein of HQ0412; PRKMK4; SERK1; SSK2/SSK22 MAP kinase kinase kinase, yeast, homolog of
基因别名: KIAA0213; MAP3K4; MAPKKK4; MEKK 4; MEKK4; MTK1; PRO0412
UniProt ID: (Human) Q9Y6R4
Entrez Gene ID: (Human) 4216
MAPK cascade
activation of MAPKK activity
placenta development
response to UV-C
regulation of gene expression
male germ-line sex determination
positive regulation of telomere maintenance via telomerase
intracellular signal transduction
positive regulation of JUN kinase activity
positive regulation of telomerase activity
chorionic trophoblast cell differentiation
positive regulation of p38MAPK cascade
positive regulation of telomere capping
