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MIOS Antibody (PA5-60162) in ICC/IF
Immunofluorecent analysis of MIOS in human cell line A-431 using MIOS Polyclonal Antibody (Product # PA5-60162). Staining shows localization to nucleoplasm, cytosol and cell junctions.
产品信息
PA5-60162
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
Unconjugated
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2643976
产品详细信息
Immunogen sequence: ACKFLSDTQL NRYIEKLTNE MKEAGNLEGI LLTGLTKDGV DLMESYVDRT GDVQTASYCM LQGSPLDVLK DERVQYWIEN YRNLLDAWRF WHKRAEFDIH RSKLDPSSKP LAQVFVSCNF CG
Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%.
靶标信息
As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLJ20323; GATOR2 complex protein MIOS; H_DJ1159O04.1; Missing oocyte meiosis regulator homolog; missing oocyte, meiosis regulator, homolog; WUGSC:H_DJ1159O04.1
基因别名: MIO; MIOS; Sea4
UniProt ID: (Human) Q9NXC5
Entrez Gene ID: (Human) 54468
