NeoBiotechnologies

MLH1 (MutL Homolog 1)/HNPCC Recombinant Rabbit Monoclonal Antibody (MLH1/8855R)

MLH1 (MutL Homolog 1)/HNPCC Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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MLH1 (MutL Homolog 1)/HNPCC Antibody (4292-RBM17-P1ABX) in IHC (P)

Formalin-fixed, paraffin-embedded human colon stained with MLH1 Recombinant Rabbit Monoclonal (MLH1/8855R). HIER: Tris/EDTA, pH9.0, 45 min. 2°C: HRP-polymer, 30 min. DAB, 5 min.

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产品信息

4292-RBM17-P1ABX

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

1-2 µg/mL

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG, kappa

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

MLH1/8855R

抗原

Recombinant full-length human MLH1 protein

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A/G

保存液

PBS

内含物

no preservative

保存条件

-20°C or -80°C if preferred

运输条件

Ambient (domestic); Dry ice (international)

产品详细信息

Positive Control:Human tonsil or colon carcinoma.

Cellular Location: Nucleus.

靶标信息

MLH1 is a DNA mismatch repair protein. The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. The importance of mismatch repair genes became apparent with the identification of the genetic basis for hereditary nonpolyposis colon cancer (HNPC). MSHS2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process. It is thought that after MSH2 binds to a mismatched DNA duplex it is joined by a heterodimer of MLH1 and PMSH, which together help facilitate the later steps in mismatch repair.

仅用于科研。不用于诊断过程。未经明确授权不得转售。