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MRP2 Antibody (MA5-42921) in WB
Western blot analysis of MRP2 in extracts of various cell lines. Samples were incubated with MRP2 Monoclonal antibody (Product # MA5-42921) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 180s.
产品信息
MA5-42921
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
6L3Z6
抗原
A synthetic peptide corresponding to a sequence within amino acids 1446-1545 of human MRP2/ABCC2 (Q92887).
偶联物
形式
Liquid
浓度
1.5 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2912062
产品详细信息
Positive test controls include: HepG2, A-549.
Immunogen sequence: CLGRALLRKS KILVLDEATA AVDLETDNLI QTTIQNEFAH CTVITIAHRL HTIMDSDKVM VLDNGKIIEC GSPEELLQIP GPFYFMAKEA GIENVNSTKF
靶标信息
This gene encodes the prototype of the membrane-associated guanylate kinase (MAGUK) family proteins. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. The encoded protein is an extensively palmitoylated membrane phosphoprotein containing a PDZ domain, a Src homology 3 (SH3) motif, and a guanylate kinase domain. This gene product interacts with various cytoskeletal proteins and cell junctional proteins in different tissue and cell types, and may be involved in the regulation of cell shape, hair cell development, neural patterning of the retina, and apico-basal polarity and tumor suppression pathways in non-erythroid cells. Multiple transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ATP-binding cassette sub-family C member 2; ATP-binding cassette, sub-family C (CFTR/MRP), member 2; Canalicular multidrug resistance protein; Canalicular multispecific organic anion transporter 1; Human MRP2; KIAA1010; Multidrug resistance-associated protein 2
基因别名: ABC30; ABCC2; CMOAT; CMOAT1; CMRP; DJS; MRP2
UniProt ID: (Human) Q92887
Entrez Gene ID: (Human) 1244
protein binding
ATP binding
organic anion transmembrane transporter activity
bilirubin transmembrane transporter activity
protein domain specific binding
ATPase activity, coupled to transmembrane movement of substances
anion transmembrane-transporting ATPase activity
ATP-binding cassette (ABC) transporter
transport
drug transmembrane transport
response to oxidative stress
response to heat
bilirubin transport
prostaglandin transport
cellular chloride ion homeostasis
response to methotrexate
response to estrogen
response to arsenic-containing substance
response to steroid hormone
transmembrane transport
thyroid hormone transport
anion transmembrane transport
