Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
产品信息
H00004487-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
MSX1 (AAH67353.1, 1 a.a. approximately 297 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MTSLPLGVKV EDSAFGKPAG GGAGQAPSAA AATAAAMGAD EEGAKPKVSP SLLPFSVEAL MADHRKPGAK ESALAPSEGV QAAGGSAQPL GVPPGSLGAP DAPSSPRPLG HFSVGGLLKL PEDALVKAES PEKPERTPWM QSPRFSPPPA RRLSPPACTL RKHKTNRKPR TPFTTAQLLA LERKFRQKQY LSIAERAEFS SSLSLTETQV KIWFQNRRAK AKRLQEAELE KLKMAAKPML PPAAFGLSFP LGGPAAVAAA AGASLYGASG PFQRAALPVA PVGLYTAHVG YSMYHLT
靶标信息
MSX1 is a member of the muscle segment homeobox gene family. It functions as a transcriptional repressor during embryogenesis through interactions with components of the core transcription complex and other homeoproteins. MSX1 may also have roles in limb-pattern formation, craniofacial development, particularly odontogenesis, and tumor growth inhibition. Mutations in the gene, which was once known as homeobox 7, have been associated with nonsyndromic cleft lip with or without cleft palate 5, Witkop syndrome, Wolf-Hirschom syndrome, and autosomoal dominant hypodontia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: homeobox 7; Homeobox protein Hox-7; Homeobox protein MSX-1; msh homeo box 1; Msh homeobox 1-like protein; msh homeobox homolog 1
基因别名: ECTD3; HOX7; HYD1; MSX1; STHAG1
UniProt ID: (Human) P28360
Entrez Gene ID: (Human) 4487
RNA polymerase II regulatory region sequence-specific DNA binding
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
p53 binding
homeodomain transcription factor
negative regulation of transcription from RNA polymerase II promoter
cell morphogenesis
in utero embryonic development
epithelial to mesenchymal transition involved in endocardial cushion formation
transcription from RNA polymerase II promoter
muscle organ development
negative regulation of cell proliferation
anterior/posterior pattern specification
mesenchymal cell proliferation
signal transduction involved in regulation of gene expression
negative regulation of cell growth
positive regulation of BMP signaling pathway
forebrain development
midbrain development
protein localization to nucleus
embryonic forelimb morphogenesis
embryonic hindlimb morphogenesis
embryonic nail plate morphogenesis
middle ear morphogenesis
odontogenesis of dentin-containing tooth
regulation of odontogenesis
negative regulation of apoptotic process
positive regulation of DNA damage response, signal transduction by p53 class mediator
positive regulation of transcription from RNA polymerase II promoter
stem cell differentiation
protein stabilization
negative regulation of striated muscle cell differentiation
palate development
face morphogenesis
bone morphogenesis
cartilage morphogenesis
mammary gland epithelium development
BMP signaling pathway involved in heart development
activation of meiosis
positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
negative regulation of transcription regulatory region DNA binding
positive regulation of mesenchymal cell apoptotic process
