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产品信息
H00004487-M11
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
1E2
抗原
MSX1 (NP_002439, 216 a.a. approximately 297 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: NRRAKAKRLQ EAELEKLKMA AKPMLPPAAF GLSFPLGGPA AVAAAAGASL YGASGPFQRA ALPVAPVGLY TAHVGYSMYH LT
靶标信息
MSX1 is a member of the muscle segment homeobox gene family. It functions as a transcriptional repressor during embryogenesis through interactions with components of the core transcription complex and other homeoproteins. MSX1 may also have roles in limb-pattern formation, craniofacial development, particularly odontogenesis, and tumor growth inhibition. Mutations in the gene, which was once known as homeobox 7, have been associated with nonsyndromic cleft lip with or without cleft palate 5, Witkop syndrome, Wolf-Hirschom syndrome, and autosomoal dominant hypodontia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: homeo box, msh-like 1; homeobox 7; Homeobox protein Hox-7; Homeobox protein MSX-1; homeobox, msh-like 1; Hox-7.1; msh homeo box 1; Msh homeobox 1-like protein; msh homeobox homolog 1; muscle-segment homeobox
基因别名: AA675338; AI324650; ECTD3; Hox-7; HOX7; Hox7.1; HYD1; msh; MSX1; STHAG1
UniProt ID: (Human) P28360, (Mouse) P13297
Entrez Gene ID: (Human) 4487, (Mouse) 17701
RNA polymerase II regulatory region sequence-specific DNA binding
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
p53 binding
DNA binding
protein binding
sequence-specific DNA binding
homeodomain transcription factor
negative regulation of transcription from RNA polymerase II promoter
cell morphogenesis
in utero embryonic development
epithelial to mesenchymal transition involved in endocardial cushion formation
transcription from RNA polymerase II promoter
muscle organ development
negative regulation of cell proliferation
anterior/posterior pattern specification
mesenchymal cell proliferation
signal transduction involved in regulation of gene expression
negative regulation of cell growth
positive regulation of BMP signaling pathway
forebrain development
midbrain development
protein localization to nucleus
embryonic forelimb morphogenesis
embryonic hindlimb morphogenesis
embryonic nail plate morphogenesis
middle ear morphogenesis
odontogenesis of dentin-containing tooth
regulation of odontogenesis
negative regulation of apoptotic process
positive regulation of DNA damage response, signal transduction by p53 class mediator
positive regulation of transcription from RNA polymerase II promoter
stem cell differentiation
protein stabilization
negative regulation of striated muscle cell differentiation
palate development
face morphogenesis
bone morphogenesis
cartilage morphogenesis
mammary gland epithelium development
BMP signaling pathway involved in heart development
activation of meiosis
positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
negative regulation of transcription regulatory region DNA binding
positive regulation of mesenchymal cell apoptotic process
epithelial to mesenchymal transition
heart morphogenesis
transcription, DNA-templated
regulation of transcription, DNA-templated
multicellular organism development
heart development
embryonic limb morphogenesis
BMP signaling pathway
odontogenesis
embryonic digit morphogenesis
negative regulation of DNA binding
negative regulation of transcription, DNA-templated
cartilage development
