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Invitrogen

MSX1/MSX2 Polyclonal Antibody

说明书
实验方案
技术支持
说明书
实验方案
技术支持

产品信息

PA5-103302

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000-1:3,000
-

免疫细胞化学 (ICC/IF)

1:100-1:500
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human MSX1(Accession P28360), corresponding to amino acid residues W145-Q195.
查看免疫原

偶联物

Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2852649

产品详细信息

Antibody detects endogenous levels of total MSX1/2.

靶标信息

Drosophila,muscle segment (msh) homolog 1,homeo domain encoding gene,inhibiting MYOD1 expression,highly expressed in dental mesenchyme during critical bud stage,involved in epithelial-mesenchymal signaling in many organs,and in the pathogenesis of cleft lip and palate,interacting with MSX2 in mouse limb bud patterning .This gene encodes a member of the muscle segment homeobox gene family. The encoded protein functions as a transcriptional repressor during embryogenesis through interactions with components of the core transcription complex and other homeoproteins. It may also have roles in limb-pattern formation, craniofacial development, particularly odontogenesis, and tumor growth inhibition.Tissue specificity: Expressed in the developing nail bed mesenchyme.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: homeo box, msh-like 1; homeo box, msh-like 2; homeobox 7; Homeobox protein Hox-7; Homeobox protein Hox-8; Homeobox protein Hox-8-1; Homeobox protein MSX-1; Homeobox protein MSX-2; homeobox, msh-like 1; homeobox, msh-like 2; Hox-7.1; hox-8.1; msh homeo box 1; msh homeo box 2; msh homeo box homolog 2; Msh homeobox 1-like protein; msh homeobox homolog 1; msh homeobox homolog 2; muscle-segment homeobox

基因别名: AA675338; AI324650; BB122635; CRS2; ECTD3; FPP; Hox-7; Hox-8; Hox-8.1; HOX7; Hox7.1; HOX8; Hox8.1; HYD1; MSH; Msx-2; MSX1; MSX2; PFM; PFM1; STHAG1

UniProt ID: (Human) P28360, (Human) P35548, (Mouse) P13297, (Mouse) Q03358

Entrez Gene ID: (Human) 4487, (Human) 4488, (Mouse) 17701, (Rat) 81710, (Mouse) 17702, (Rat) 25483

功能
RNA polymerase II regulatory region sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding p53 binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription cofactor activity protein binding transcription factor binding sequence-specific DNA binding transcription regulatory region DNA binding DNA binding molecular_function transcription factor activity, transcription factor binding homeodomain transcription factor
参与通路
negative regulation of transcription from RNA polymerase II promoter cell morphogenesis in utero embryonic development epithelial to mesenchymal transition involved in endocardial cushion formation transcription from RNA polymerase II promoter muscle organ development negative regulation of cell proliferation anterior/posterior pattern specification mesenchymal cell proliferation signal transduction involved in regulation of gene expression negative regulation of cell growth positive regulation of BMP signaling pathway forebrain development midbrain development protein localization to nucleus embryonic forelimb morphogenesis embryonic hindlimb morphogenesis embryonic nail plate morphogenesis middle ear morphogenesis odontogenesis of dentin-containing tooth regulation of odontogenesis negative regulation of apoptotic process positive regulation of DNA damage response, signal transduction by p53 class mediator positive regulation of transcription from RNA polymerase II promoter stem cell differentiation protein stabilization negative regulation of striated muscle cell differentiation palate development face morphogenesis bone morphogenesis cartilage morphogenesis mammary gland epithelium development BMP signaling pathway involved in heart development activation of meiosis positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator negative regulation of transcription regulatory region DNA binding positive regulation of mesenchymal cell apoptotic process osteoblast differentiation chondrocyte development osteoblast development outflow tract septum morphogenesis endochondral bone growth negative regulation of CREB transcription factor activity wound healing, spreading of epidermal cells negative regulation of fat cell differentiation negative regulation of keratinocyte differentiation positive regulation of osteoblast differentiation negative regulation of transcription, DNA-templated positive regulation of catagen bone trabecula formation cranial suture morphogenesis frontal suture morphogenesis branching involved in mammary gland duct morphogenesis enamel mineralization cellular response to estradiol stimulus epithelial to mesenchymal transition heart morphogenesis transcription, DNA-templated regulation of transcription, DNA-templated multicellular organism development heart development embryonic limb morphogenesis BMP signaling pathway odontogenesis embryonic digit morphogenesis negative regulation of DNA binding cartilage development pituitary gland development cellular response to nicotine ossification outflow tract morphogenesis regulation of transcription from RNA polymerase II promoter wound healing anagen regulation of apoptotic process positive regulation of apoptotic process cellular response to growth factor stimulus
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