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产品信息
PA5-40367
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide directed towards the N-terminal of human MSX2 (aa 1-50).
偶联物
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2608897
产品详细信息
Peptide sequence: MASPSKGNDL FSPDEEGPAV VAGPGPGPGG AEGAAEERRV KVSSLPFSVE
Sequence homology: Cow: 100%; Dog: 100%; Horse: 100%; Human: 100%; Mouse: 91%; Rabbit: 91%; Rat: 91%
靶标信息
Msx2 is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. This protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in the Msx2 gene are associated with parietal foramina 1 and craniosynostosis type 2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: homeo box, msh-like 2; Homeobox protein Hox-8-1; Homeobox protein MSX-2; homeobox, msh-like 2
基因别名: BB122635; Hox-8; Hox-8.1; Hox8; Hox8.1; Msx-2; Msx2
UniProt ID: (Mouse) Q03358
Entrez Gene ID: (Mouse) 17702
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, transcription factor binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription cofactor activity
protein binding
transcription factor binding
sequence-specific DNA binding
transcription regulatory region DNA binding
homeodomain transcription factor
negative regulation of transcription from RNA polymerase II promoter
ossification
osteoblast differentiation
chondrocyte development
osteoblast development
outflow tract septum morphogenesis
outflow tract morphogenesis
epithelial to mesenchymal transition involved in endocardial cushion formation
endochondral bone growth
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
multicellular organism development
negative regulation of cell proliferation
anterior/posterior pattern specification
signal transduction involved in regulation of gene expression
embryonic limb morphogenesis
BMP signaling pathway
positive regulation of BMP signaling pathway
negative regulation of CREB transcription factor activity
embryonic forelimb morphogenesis
embryonic hindlimb morphogenesis
wound healing, spreading of epidermal cells
embryonic nail plate morphogenesis
wound healing
odontogenesis
anagen
embryonic digit morphogenesis
regulation of apoptotic process
positive regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of fat cell differentiation
negative regulation of keratinocyte differentiation
positive regulation of osteoblast differentiation
negative regulation of transcription, DNA-templated
stem cell differentiation
cartilage development
positive regulation of catagen
bone trabecula formation
bone morphogenesis
frontal suture morphogenesis
branching involved in mammary gland duct morphogenesis
mammary gland epithelium development
BMP signaling pathway involved in heart development
enamel mineralization
cellular response to growth factor stimulus
cellular response to estradiol stimulus
activation of meiosis
negative regulation of transcription regulatory region DNA binding
positive regulation of mesenchymal cell apoptotic process
