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Immunogen sequence: PNFMVLIATS VETSAASGSP EGAGMTTVQT ITGSDPEEAI FDTLCTDDSS EEAKTLTMDI LTLAHTSTEA KGLSSESSAS SDGPHPVITP SRASESSASS D; Positive Samples: 293T, A-549, DU145, LO2, U-251MG, HT-29, Mouse kidney, Mouse lung, Rat kidney; Cellular Location: Apical cell membrane, Basolateral cell membrane, Cell projection, microvillus membrane
This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins secreted by many epithelial tissues to form an insoluble mucous barrier. The shorter isoform expressed by this gene is localized to the plasma membrane, whereas the longer isoform might be secreted. The C terminus of this protein associates with the multifunctional docking site of the met proto-oncogene and suppresses activation of some downstream met signaling cascades. The protein features a tandem repeat domain that varies between 2 and 6 copies in most individuals. The allele represented in the human reference assembly contains 12 copies. Multiple transcript variants encoding different isoforms have been found for this gene.
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仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: MUC-20; Mucin-20; transmembrane mucin MUC20S
基因别名: BC026367; KIAA1359; MUC-20; MUC20; UNQ2782/PRO7170
UniProt ID: (Human) Q8N307, (Mouse) Q8BUE7
Entrez Gene ID: (Human) 200958, (Mouse) 224116, (Rat) 303886