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Invitrogen
MYH6 Monoclonal Antibody (GT5612)
高级验证
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
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MYH6 Antibody (MA5-27819) in WB
Western blot was performed using Anti-MYH6 Monoclonal Antibody (GT5612) (Product # MA5-27819) and a 240 kDa band corresponding to MYH6 was observed only in Mouse Heart when compared to other tissue extracts tested which are reported to be low. Tissue extracts (30 µg lysate) of Mouse Heart (Lane 1), Mouse Skeletal Muscle (Lane 2), Mouse Liver (Lane 3), Mouse Brain (Lane 4), Mouse Kidney (Lane 5) and Mouse Lung (Lane 6) were electrophoresed using Novex® NuPAGE® 4-12 % Bis-Tris gel (Product # NP0322BOX). Resolved proteins were then transferre... View More
产品信息
MA5-27819
产品规格
种属反应
Human,
Mouse
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
GT5612
抗原
Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human MYH6. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1.18 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2735280
产品详细信息
Predicted Reactivity: Human (100%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Cardiac muscle myosin is a hexamer consisting of two heavy chain subunits, two light chain subunits, and two regulatory subunits. This gene encodes the alpha heavy chain subunit of cardiac myosin. The gene is located approximately 4kb downstream of the gene encoding the beta heavy chain subunit of cardiac myosin. Mutations in this gene cause familial hypertrophic cardiomyopathy and atrial septal defect 3.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: alpha cardiac MHC; alpha myosin; cardiac myosin heavy chain alpha isoform; cardiomyopathy, hypertrophic 1; MyHC-alpha; myosin 6; Myosin heavy chain 6; Myosin heavy chain, cardiac muscle alpha isoform; Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha); myosin heavy chain, cardiac muscle, adult; myosin, heavy polypeptide 6, cardiac muscle, alpha (cardiomyopathy, hypertrophic 1); Myosin-6
基因别名: A830009F23Rik; AA517445; alpha-MHC; ASD3; CMD1EE; CMH14; MYH6; MYHC; Myhc-a; MYHCA; SSS3
UniProt ID: (Human) P13533, (Mouse) Q02566
Entrez Gene ID: (Human) 4624, (Mouse) 17888
microfilament motor activity
actin binding
calmodulin binding
ATP binding
ATPase activity
myosin phosphatase activity
protein kinase binding
actin-dependent ATPase activity
nucleotide binding
motor activity
protein binding
calcium-dependent ATPase activity
identical protein binding
protein homodimerization activity
protein heterodimerization activity
in utero embryonic development
regulation of the force of heart contraction
regulation of heart rate
muscle contraction
striated muscle contraction
adult heart development
visceral muscle development
regulation of heart contraction
metabolic process
regulation of blood pressure
actin filament-based movement
muscle filament sliding
myofibril assembly
BMP signaling pathway
regulation of ATPase activity
sarcomere organization
ATP metabolic process
cardiac muscle fiber development
atrial cardiac muscle tissue morphogenesis
ventricular cardiac muscle tissue morphogenesis
cardiac muscle contraction
canonical Wnt signaling pathway
regulation of heart growth
protein dephosphorylation
