Product References
CENP-F-dependent DRP1 function regulates APC/C activity during oocyte meiosis I.
Nature communications
Zhou CJ,Wang XY,Dong YH,Wang DH,Han Z,Zhang XJ,Sun QY,Carroll J,Liang CG
R950-25 was used in ELISA, Western Blot, Immunohistochemistry to show that DRP1 is a CENP-F-dependent atypical spindle assembly checkpoint (SAC) protein that modulates metaphase-to-anaphase transition by controlling APC/C activity during meiosis I in oocytes.
Tue Dec 13 00:00:00 EST 2022
CENP-F-dependent DRP1 function regulates APC/C activity during oocyte meiosis I.
Nature communications
Zhou CJ,Wang XY,Dong YH,Wang DH,Han Z,Zhang XJ,Sun QY,Carroll J,Liang CG
R950-25 was used in ELISA, Western Blot, Immunohistochemistry to show that DRP1 is a CENP-F-dependent atypical spindle assembly checkpoint (SAC) protein that modulates metaphase-to-anaphase transition by controlling APC/C activity during meiosis I in oocytes.
Tue Dec 13 00:00:00 EST 2022
TIR domains of plant immune receptors are 2',3'-cAMP/cGMP synthetases mediating cell death.
Cell
Yu D,Song W,Tan EYJ,Liu L,Cao Y,Jirschitzka J,Li E,Logemann E,Xu C,Huang S,Jia A,Chang X,Han Z,Wu B,Schulze-Lefert P,Chai J
R950-25 was used in Western Blotting to identify a family of 2',3'-cAMP/cGMP synthetases and establishes a critical role for them in plant immune responses.
Thu Jun 23 00:00:00 EDT 2022
The ARF GAPs ELMOD1 and ELMOD3 act at the Golgi and cilia to regulate ciliogenesis and ciliary protein traffic.
Molecular biology of the cell
Turn RE,Hu Y,Dewees SI,Devi N,East MP,Hardin KR,Khatib T,Linnert J,Wolfrum U,Lim MJ,Casanova JE,Caspary T,Kahn RA
R950-25 was used in Western Blotting to find strong similarities in phenotypes resulting from deletion of either Elmod1 or Elmod3 and marked differences from those arising in Elmod2 deletion lines.
Tue Feb 01 00:00:00 EST 2022
Co-opting regulation bypass repair as a gene-correction strategy for monogenic diseases.
Molecular therapy : the journal of the American Society of Gene Therapy
Hu J,Bourne RA,McGrath BC,Lin A,Pei Z,Cavener DR
R950-25 was used in Western Blot to develop a novel gene-correction strategy, co-opting regulation bypass repair (CRBR), which can repair a spectrum of mutations in mitotic or post-mitotic cells and tissues.
Wed Nov 03 00:00:00 EDT 2021
NAA10 p.(N101K) disrupts N-terminal acetyltransferase complex NatA and is associated with developmental delay and hemihypertrophy.
European journal of human genetics : EJHG
McTiernan N,Gill H,Prada CE,Pachajoa H,Lores J,Arnesen T
R950-25 was used in Western Blotting to identify the previously undescribed NAA10 c.303C>A and c.303C>G p.(N101K) variants in two unrelated girls.
Mon Feb 01 00:00:00 EST 2021
Roles for ELMOD2 and Rootletin in ciliogenesis.
Molecular biology of the cell
Turn RE,Linnert J,Gigante ED,Wolfrum U,Caspary T,Kahn RA
R950-25 was used in Immunocytochemistry to propose that ARL2, ELMOD2, and Rootletin all act in a common pathway that suppresses spurious ciliation and maintains centrosome cohesion.
Thu Apr 15 00:00:00 EDT 2021
GSNOR facilitates antiviral innate immunity by restricting TBK1 cysteine S-nitrosation.
Redox biology
Liu Q,Gu T,Su LY,Jiao L,Qiao X,Xu M,Xie T,Yang LX,Yu D,Xu L,Chen C,Yao YG
R950-25 was used in Western Blotting to indicate that GSNOR is a critical regulator of antiviral responses and S-nitrosation is actively involved in innate immunity.
Mon Nov 01 00:00:00 EDT 2021
ABAS1 from soybean is a 1R-subtype MYB transcriptional repressor that enhances ABA sensitivity.
Journal of experimental botany
Ku YS,Ni M,Muñoz NB,Xiao Z,Lo AW,Chen P,Li MW,Cheung MY,Xie M,Lam HM
R950-25 was used in Western Blotting to demonstrate that a 1R-subtype of MYB from soybean enhances ABA sensitivity by acting as a transcriptional repressor.
Sat May 30 00:00:00 EDT 2020
8‑Gingerol regulates colorectal cancer cell proliferation and migration through the EGFR/STAT/ERK pathway.
International journal of oncology
Hu SM,Yao XH,Hao YH,Pan AH,Zhou XW
R950-25 was used in Western Blot to suggest that 8‚gingerol may be a promising candidate for the development of novel anticancer agents against CRC.
Wed Jan 01 00:00:00 EST 2020
The yeast FIT2 homologs are necessary to maintain cellular proteostasis and membrane lipid homeostasis.
Journal of cell science
Yap WS,Shyu P,Gaspar ML,Jesch SA,Marvalim C,Prinz WA,Henry SA,Thibault G
R950-25 was used in Western Blot to develop a model to study the role of the Saccharomyces cerevisiae fat storage-inducing transmembrane homologue.
Thu Nov 05 00:00:00 EST 2020
The MyMOMA domain of MYO19 encodes for distinct Miro-dependent and Miro-independent mechanisms of interaction with mitochondrial membranes.
Cytoskeleton (Hoboken, N.J.)
Bocanegra JL,Fujita BM,Melton NR,Cowan JM,Schinski EL,Tamir TY,Major MB,Quintero OA
R950-25 was used in Western Blot to investigate if membrane-inserted MYO19 is part of a larger complex, and if Miro2 plays a role in integration of actin- and microtubule-based mitochondrial activities.
Sun Mar 01 00:00:00 EST 2020
Interferon Alpha Favors Macrophage Infection by Visceral Leishmania Species Through Upregulation of Sialoadhesin Expression.
Frontiers in immunology
Van Bockstal L,Bulté D,Van den Kerkhof M,Dirkx L,Mabille D,Hendrickx S,Delputte P,Maes L,Caljon G
R950-25 was used in Immunocytochemistry to assess the impact of type I IFN on macrophage infection with L. infantum and L. donovani and the implication of sialoadhesin as an IFN-inducible surface receptor.
Fri Apr 02 00:00:00 EDT 2021
Molecular Stressors Engender Protein Connectivity Dysfunction through Aberrant N-Glycosylation of a Chaperone.
Cell reports
Yan P,Patel HJ,Sharma S,Corben A,Wang T,Panchal P,Yang C,Sun W,Araujo TL,Rodina A,Joshi S,Robzyk K,Gandu S,White JR,de Stanchina E,Modi S,Janjigian YY,Hill EG,Liu B,Erdjument-Bromage H,Neubert TA,Que NLS,Li Z,Gewirth DT,Taldone T,Chiosis G
R950-25 was used in Western Blotting to unveils a specific N-glycosylation pattern used by a chaperone, Glucose-regulated protein 94 (GRP94), to alter its conformational fitness and stabilize a state most permissive for stable interactions with proteins at the plasma membrane.
Tue Jun 30 00:00:00 EDT 2020
Modulation of antibiotic sensitivity and biofilm formation in Pseudomonas aeruginosa by interspecies signal analogues.
Nature communications
An SQ,Murtagh J,Twomey KB,Gupta MK,O'Sullivan TP,Ingram R,Valvano MA,Tang JL
R950-25 was used in Western Blotting to examine the ability of synthetic DSF analogues to modulate or inhibit PA1396 activity which may represent lead compounds to develop novel adjuvants to improve the efficacy of existing antibiotics.
Mon May 27 00:00:00 EDT 2019
CAR exosomes derived from effector CAR-T cells have potent antitumour effects and low toxicity.
Nature communications
Fu W,Lei C,Liu S,Cui Y,Wang C,Qian K,Li T,Shen Y,Fan X,Lin F,Ding M,Pan M,Ye X,Yang Y,Hu S
R950-25 was used in an ELISA assay to show CAR-T cells release CAR-containing exosomes that express cytotoxic molecules and provide inhibition of tumour growth.
Wed Sep 25 00:00:00 EDT 2019
BAG3 promotes autophagy and glutaminolysis via stabilizing glutaminase.
Cell death & disease
Zhao S,Wang JM,Yan J,Zhang DL,Liu BQ,Jiang JY,Li C,Li S,Meng XN,Wang HQ
R950-25 was used in Western Blotting to study the mechanism underlying regualtion of autophagy by BAG3.
Mon Mar 25 00:00:00 EDT 2019
The Adhesion G Protein-Coupled Receptor GPR97/ADGRG3 Is Expressed in Human Granulocytes and Triggers Antimicrobial Effector Functions.
Frontiers in immunology
Hsiao CC,Chu TY,Wu CJ,van den Biggelaar M,Pabst C,Hébert J,Kuijpers TW,Scicluna BP,I KY,Chen TC,Liebscher I,Hamann J,Lin HH
R950-25 was used in Western Blotting to study the cellular distribution, molecular structure, signal transduction, and biological function of GPR97 in polymorphonuclear cells.
Thu Oct 03 00:00:00 EDT 2019
Cox15 interacts with the cytochrome bc1 dimer within respiratory supercomplexes as well as in the absence of cytochrome c oxidase.
The Journal of biological chemistry
Herwaldt EJ,Rivett ED,White AJ,Hegg EL
R950-25 was used in Western Blotting to investigate the protein-protein interactions that involve Cox15 in S. cerevisiae.
Fri Oct 19 00:00:00 EDT 2018
ZNF281 enhances cardiac reprogramming by modulating cardiac and inflammatory gene expression.
Genes & development
Zhou H,Morales MG,Hashimoto H,Dickson ME,Song K,Ye W,Kim MS,Niederstrasser H,Wang Z,Chen B,Posner BA,Bassel-Duby R,Olson EN
R950-25 was used in Western Blotting to conclude that ZNF281is a nexus of cardiac and inflammatory gene programs, which exert opposing influences on fibroblast to cardiac reprogramming.
Fri Sep 01 00:00:00 EDT 2017
An in vitro technique to identify the RNA binding-site sequences for RNA-binding proteins.
BioTechniques
Choi S,Park C,Kim KE,Kim KK
R950-25 was used in Western Blotting to identify the RNA binding site consensus sequences for RNA binding proteins.
Sat Jul 01 00:00:00 EDT 2017
Global Analysis of SUMO-Binding Proteins Identifies SUMOylation as a Key Regulator of the INO80 Chromatin Remodeling Complex.
Molecular & cellular proteomics : MCP
Cox E,Hwang W,Uzoma I,Hu J,Guzzo CM,Jeong J,Matunis MJ,Qian J,Zhu H,Blackshaw S
R950-25 was used in Immunoprecipitation to identify human proteins whose interaction is modulated by SUMOylation.
Mon May 01 00:00:00 EDT 2017
Global Analysis of SUMO-Binding Proteins Identifies SUMOylation as a Key Regulator of the INO80 Chromatin Remodeling Complex.
Molecular & cellular proteomics : MCP
Cox E,Hwang W,Uzoma I,Hu J,Guzzo CM,Jeong J,Matunis MJ,Qian J,Zhu H,Blackshaw S
R950-25 was used in Immunoprecipitation to identify human proteins whose interaction is modulated by SUMOylation.
Mon May 01 00:00:00 EDT 2017
Histone Hypervariants H2A.Z.1 and H2A.Z.2 Play Independent and Context-Specific Roles in Neuronal Activity-Induced Transcription of Arc/Arg3.1 and Other Immediate Early Genes.
eNeuro
Dunn CJ,Sarkar P,Bailey ER,Farris S,Zhao M,Ward JM,Dudek SM,Saha RN
R950-25 was used in Immunocytochemistry to suggest that H2A.Z hypervariants have context-specific roles that complement each other to mediate activity-induced neuronal gene transcription.
Mon Sep 17 00:00:00 EDT 2018
Chromosomal instability induced by increased BIRC5/Survivin levels affects tumorigenicity of glioma cells.
BMC cancer
Conde M,Michen S,Wiedemuth R,Klink B,Schröck E,Schackert G,Temme A
R950-25 was used in Western Blotting to show that increased Survivin levels promote adaptive evolution of tumours through combining induction of genetic heterogeneity with inhibition of apoptosis.
Thu Dec 28 00:00:00 EST 2017
The ARL2 GTPase regulates mitochondrial fusion from the intermembrane space.
Cellular logistics
Newman LE,Schiavon CR,Turn RE,Kahn RA
R950-25 was used in Immunocytochemistry-immunoflourescence to examine whether ARL2 GTPase plays a regulatory role in mitochondrial fusion.
Thu Oct 01 00:00:00 EDT 2020
The GPR139 reference agonists 1a and 7c, and tryptophan and phenylalanine share a common binding site.
Scientific reports
Nøhr AC,Jespers W,Shehata MA,Floryan L,Isberg V,Andersen KB,Åqvist J,Gutiérrez-de-Terán H,Bräuner-Osborne H,Gloriam DE
R950-25 was used in an ELISA assay to discover that the GPR139 surrogate agonists 1a and 7c, and amino acids L-Trp and L-Phe share a common binding site.
Tue Apr 25 00:00:00 EDT 2017
Genetic Variations in the Human G Protein-coupled Receptor Class C, Group 6, Member A (GPRC6A) Control Cell Surface Expression and Function.
The Journal of biological chemistry
Jørgensen S,Have CT,Underwood CR,Johansen LD,Wellendorph P,Gjesing AP,Jørgensen CV,Quan S,Rui G,Inoue A,Linneberg A,Grarup N,Jun W,Pedersen O,Hansen T,Bräuner-Osborne H
R950-25 was used in an ELISA assay to solve a decade-old question of why the cloned human GPRC6A receptor is not cell surface-expressed and functional.
Fri Jan 27 00:00:00 EST 2017
Ten-eleven translocation 2 interacts with forkhead box O3 and regulates adult neurogenesis.
Nature communications
Li X,Yao B,Chen L,Kang Y,Li Y,Cheng Y,Li L,Lin L,Wang Z,Wang M,Pan F,Dai Q,Zhang W,Wu H,Shu Q,Qin Z,He C,Xu M,Jin P
R950-25 was used in Western blot to establish a role for the ten-eleven translocation (Tet2)-forkhead box O3 (Foxo3a) axis in epigenetically regulating critical genes in adult neural stem cells during adult neurogenesis.
Thu Jun 29 00:00:00 EDT 2017
Ten-eleven translocation 2 interacts with forkhead box O3 and regulates adult neurogenesis.
Nature communications
Li X,Yao B,Chen L,Kang Y,Li Y,Cheng Y,Li L,Lin L,Wang Z,Wang M,Pan F,Dai Q,Zhang W,Wu H,Shu Q,Qin Z,He C,Xu M,Jin P
R950-25 was used in Western blot to establish a role for the ten-eleven translocation (Tet2)-forkhead box O3 (Foxo3a) axis in epigenetically regulating critical genes in adult neural stem cells during adult neurogenesis.
Thu Jun 29 00:00:00 EDT 2017
Human, Pig, and Mouse Interferon-Induced Transmembrane Proteins Partially Restrict Pseudotyped Lentiviral Vectors.
Human gene therapy
Hornick AL,Li N,Oakland M,McCray PB,Sinn PL
R950-25 was used in western blot to characterize the partial restriction of pseudotyped lentiviral vectors by human, mouse and pig interferon-induced transmembrane proteins
Sun May 01 00:00:00 EDT 2016
The Deubiquitinase Inhibitor PR-619 Sensitizes Normal Human Fibroblasts to Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-mediated Cell Death.
The Journal of biological chemistry
Crowder RN,Dicker DT,El-Deiry WS
R950-25 was used in western blot to elucidate the deubiquitinase inhibitor PR-619 and how it sensitizes normal human fibroblasts to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated cell death
Fri Mar 11 00:00:00 EST 2016
Protein phosphatase Mg2+/Mn2+ dependent 1F promotes smoking-induced breast cancer by inactivating phosphorylated-p53-induced signals.
Oncotarget
Tu SH,Lin YC,Huang CC,Yang PS,Chang HW,Chang CH,Wu CH,Chen LC,Ho YS
R950-25 was used in Western Blotting to indicate that PPM1F may be a mediator downstream of α9-nAChR that activates smoking-induced carcinogenic signals.
Tue Nov 22 00:00:00 EST 2016
Neuropilin 1 balances β8 integrin-activated TGFβ signaling to control sprouting angiogenesis in the brain.
Development (Cambridge, England)
Hirota S,Clements TP,Tang LK,Morales JE,Lee HS,Oh SP,Rivera GM,Wagner DS,McCarty JH
R950-25 was used in western blot to report that beta8 integrin and neuropilin 1 cooperatively promote angiogenesis in the central nervous system
Tue Dec 15 00:00:00 EST 2015
Nuf2 is required for chromosome segregation during mouse oocyte meiotic maturation.
Cell cycle (Georgetown, Tex.)
Zhang T,Zhou Y,Qi ST,Wang ZB,Qian WP,Ouyang YC,Shen W,Schatten H,Sun QY
R950-25 was used in immunocytochemistry to study the localization and function of Nuf2 during mouse oocyte meiotic maturation.
Tue May 24 00:00:00 EDT 2016
The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Wong YC,Holzbaur EL
R950-25 was used in western blot to investigate the role of huntingtin in the the regulation of autophagosome dynamics.
Wed Jan 22 00:00:00 EST 2014
MicroRNAs located in the Hox gene clusters are implicated in huntington's disease pathogenesis.
PLoS genetics
Hoss AG,Kartha VK,Dong X,Latourelle JC,Dumitriu A,Hadzi TC,Macdonald ME,Gusella JF,Akbarian S,Chen JF,Weng Z,Myers RH
R950-25 was used in western blot to characterize Huntington's disease pathogenesis and microRNAs located in Hox gene clusters
Sat Feb 01 00:00:00 EST 2014
Identification of SH3 domain proteins interacting with the cytoplasmic tail of the a disintegrin and metalloprotease 10 (ADAM10).
PloS one
Ebsen H,Lettau M,Kabelitz D,Janssen O
R950-25 was used in Western Blotting to identify Src homology domain 3 (SH3) domain proteins interacting with the cytoplasmic tail of the a disintegrin and metalloprotease 10(ADAM10).
Wed Nov 04 00:00:00 EST 2015
Efg1 directly regulates ACE2 expression to mediate cross talk between the cAMP/PKA and RAM pathways during Candida albicans morphogenesis.
Eukaryotic cell
Saputo S,Kumar A,Krysan DJ
Mon Sep 01 00:00:00 EDT 2014
Pou5f1 protein expression and posttranslational modification during early zebrafish development.
Developmental dynamics : an official publication of the American Association of Anatomists
Lippok B,Song S,Driever W
R950-25 was used in Western Blotting to generate polyclonal antibodies that selectively recognize Pou5f1 and analyzed its protein distribution and modification during development.
Sat Mar 01 00:00:00 EST 2014
An R132H mutation in isocitrate dehydrogenase 1 enhances p21 expression and inhibits phosphorylation of retinoblastoma protein in glioma cells.
Neurologia medico-chirurgica
Miyata S,Urabe M,Gomi A,Nagai M,Yamaguchi T,Tsukahara T,Mizukami H,Kume A,Ozawa K,Watanabe E
R950-25 was used in Western Blotting to show that Sterol regulatory element-binding proteins are up-regulated in U87 human glioblastoma cells transfected with an cytosolic isocitrate dehydrogenase 1(R132H)-expression plasmid.
Mon Oct 06 00:00:00 EDT 2014
Effective identification of bacterial type III secretion signals using joint element features.
PloS one
Wang Y,Sun M,Bao H,Zhang Q,Guo D
R950-25 was used in Western Blotting to evidence that secondary structure and solvent accessibility contain important common features for guiding specific type III effector secretion across gram positive bacteria and yeast.
Mon Nov 04 00:00:00 EST 2013
SGO1 maintains bovine meiotic and mitotic centromeric cohesions of sister chromatids and directly affects embryo development.
PloS one
Yin FX,Li GP,Bai CL,Liu Y,Wei ZY,Liang CG,Bunch TD,Zan LS
R950-25 was used in immunocytochemistry to study the role of SGO1 in maintaining bovine mitotic and meiotic centromeric cohesions of sister chromatids and directly affect embryo development
Fri May 16 00:00:00 EDT 2014
Interplay between the HTLV-2 Tax and APH-2 proteins in the regulation of the AP-1 pathway.
Retrovirology
Marban C,McCabe A,Bukong TN,Hall WW,Sheehy N
R950-25 was used in immunoprecipitation and western blot to examine the role of APH-2 in basal and Tax2B-mediated activation of the AP-1 pathway
Mon Dec 03 00:00:00 EST 2012
Defective ribosome assembly in Shwachman-Diamond syndrome.
Blood
Wong CC,Traynor D,Basse N,Kay RR,Warren AJ
R950-25 was used in Western Blotting to support the hypothesis that Shwachman-Diamond syndrome is a ribosomopathy caused by corruption of an essential cytoplasmic step in 60S subunit maturation.
Thu Oct 20 00:00:00 EDT 2011
Endogenous axon guiding chemorepulsant semaphorin-3F inhibits the growth and metastasis of colorectal carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research
Wu F,Zhou Q,Yang J,Duan GJ,Ou JJ,Zhang R,Pan F,Peng QP,Tan H,Ping YF,Cui YH,Qian C,Yan XC,Bian XW
R950-25 was used in Western Blotting to show that endogenous SEMA3F acts as a suppressor of the growth and metastasis of human colorectal cancer cells.
Sun May 01 00:00:00 EDT 2011
Multiple functional domains and complexes of the two nonstructural proteins of human respiratory syncytial virus contribute to interferon suppression and cellular location.
Journal of virology
Swedan S,Andrews J,Majumdar T,Musiyenko A,Barik S
R950-25 was used in Western Blotting to report on the interaction, cellular localization, and functional domains of NS1 and NS2.
Sat Oct 01 00:00:00 EDT 2011
Tumor suppressor REIC/Dkk-3 interacts with the dynein light chain, Tctex-1.
Biochemical and biophysical research communications
Ochiai K,Watanabe M,Ueki H,Huang P,Fujii Y,Nasu Y,Noguchi H,Hirata T,Sakaguchi M,Huh NH,Kashiwakura Y,Kaku H,Kumon H
R950-25 was used in immunoprecipitation and western blot to identify binding partners of REIC/Dkk-3.
Fri Aug 26 00:00:00 EDT 2011
The RET51/FKBP52 complex and its involvement in Parkinson disease.
Human molecular genetics
Fusco D,Vargiolu M,Vidone M,Mariani E,Pennisi LF,Bonora E,Capellari S,Dirnberger D,Baumeister R,Martinelli P,Romeo G
R950-25 was used in Immunoprecipitation to find a compound heterozygous carrying two mutations in RET and FKBP52 that are sufficient to disrupt the RET51/FKBP52 complex, indicating its potential role in PD.
Thu Jul 15 00:00:00 EDT 2010
The RET51/FKBP52 complex and its involvement in Parkinson disease.
Human molecular genetics
Fusco D,Vargiolu M,Vidone M,Mariani E,Pennisi LF,Bonora E,Capellari S,Dirnberger D,Baumeister R,Martinelli P,Romeo G
R950-25 was used in Immunoprecipitation to find a compound heterozygous carrying two mutations in RET and FKBP52 that are sufficient to disrupt the RET51/FKBP52 complex, indicating its potential role in PD.
Thu Jul 15 00:00:00 EDT 2010
Respiratory syncytial virus nonstructural proteins decrease levels of multiple members of the cellular interferon pathways.
Journal of virology
Swedan S,Musiyenko A,Barik S
R950-25 was used in Western Blotting to show that the nonstructural proteins of respiratory syncytial virus, working individually and together, regulate key signalling molecules of both the type I interferon activation and response pathways.
Thu Oct 01 00:00:00 EDT 2009
The tyrosine kinase receptor RET interacts in vivo with aryl hydrocarbon receptor-interacting protein to alter survivin availability.
The Journal of clinical endocrinology and metabolism
Vargiolu M,Fusco D,Kurelac I,Dirnberger D,Baumeister R,Morra I,Melcarne A,Rimondini R,Romeo G,Bonora E
R950-25 was used in Immunoprecipitation to examine the mechanisms of RET-induced apoptosis.
Wed Jul 01 00:00:00 EDT 2009
A novel peripherin isoform generated by alternative translation is required for normal filament network formation.
Journal of neurochemistry
McLean J,Xiao S,Miyazaki K,Robertson J
R950-25 was used in Immunocytochemistry to identify novel processing requirements for peripherin expression and indicate a hitherto unrecognised role for neuronal intermediate filament network formation through intra-isoform associations.
Sat Mar 01 00:00:00 EST 2008
Lysosomal proliferation and distal degeneration in motor neurons expressing the G59S mutation in the p150Glued subunit of dynactin.
Human molecular genetics
Chevalier-Larsen ES,Wallace KE,Pennise CR,Holzbaur EL
R950-25 was used in immunohistochemistry - frozen section and western blot to develop and characterize a mouse model of distal spinal and bulbar muscular atrophy
Tue Jul 01 00:00:00 EDT 2008
Active gamma-secretase complexes contain only one of each component.
The Journal of biological chemistry
Sato T,Diehl TS,Narayanan S,Funamoto S,Ihara Y,De Strooper B,Steiner H,Haass C,Wolfe MS
R950-25 was used in immunoprecipitation to analyze the composition of functional gamma-secretase complexes
Fri Nov 23 00:00:00 EST 2007
The reversion-inducing cysteine-rich protein with Kazal motifs (RECK) interacts with membrane type 1 matrix metalloproteinase and CD13/aminopeptidase N and modulates their endocytic pathways.
The Journal of biological chemistry
Miki T,Takegami Y,Okawa K,Muraguchi T,Noda M,Takahashi C
R950-25 was used in Immunocytochemistry-immunoflourescence to examine the mechanism underlying the function of reversion-inducing cysteine-rich protein with Kazal motifs.
Fri Apr 20 00:00:00 EDT 2007
LMO4 can interact with Smad proteins and modulate transforming growth factor-beta signaling in epithelial cells.
Oncogene
Lu Z,Lam KS,Wang N,Xu X,Cortes M,Andersen B
R950-25 was used in Chromatin immunoprecipitation to define a new function for LMO4 as a coactivator in TGFbeta signaling, and provide a potential novel mechanism for LMO4-mediated regulation in development and oncogenesis.
Thu May 11 00:00:00 EDT 2006
Identification of an endo-beta-1,4-D-xylanase from Magnaporthe grisea by gene knockout analysis, purification, and heterologous expression.
Applied and environmental microbiology
Wu SC,Halley JE,Luttig C,Fernekes LM,Gutiérrez-Sanchez G,Darvill AG,Albersheim P
R950-25 was used in Western Blotting to establish that the XYL-6 gene encodes a secreted endo-beta-1,4-D-xylanase.
Wed Feb 01 00:00:00 EST 2006
Suppressed disassembly of autolyzing p94/CAPN3 by N2A connectin/titin in a genetic reporter system.
The Journal of biological chemistry
Ono Y,Torii F,Ojima K,Doi N,Yoshioka K,Kawabata Y,Labeit D,Labeit S,Suzuki K,Abe K,Maeda T,Sorimachi H
R950-25 was used in Immunoprecipitation to elucidate the physiological relevance of p94 undergoing very rapid and exhaustive autolysis.
Fri Jul 07 00:00:00 EDT 2006
The Salmonella enterica serovar typhimurium-encoded type III secretion systems can translocate Chlamydia trachomatis proteins into the cytosol of host cells.
Infection and immunity
Ho TD,Starnbach MN
R950-25 was used in western blot to generate an epitope tag system to examine the expression and subcellular compartmentalization of bacterial proteins during infection
Tue Feb 01 00:00:00 EST 2005
Specificity determinants and diversification of the Brassica self-incompatibility pollen ligand.
Proceedings of the National Academy of Sciences of the United States of America
Chookajorn T,Kachroo A,Ripoll DR,Clark AG,Nasrallah JB
R950-25 was used in western blot to study how changes in the amino acid sequence of the S locus cysteine-rich protein alters function
Tue Jan 27 00:00:00 EST 2004
Chromatin of the Barr body: histone and non-histone proteins associated with or excluded from the inactive X chromosome.
Human molecular genetics
Chadwick BP,Willard HF
R950-25 was used in Immunocytochemistry-immunoflourescence to study the components of the Barr body, and their relation to the chromatin configuration of the inactive X chromosome.
Mon Sep 01 00:00:00 EDT 2003
PDZ-domain interactions and apical expression of type IIa Na/P(i) cotransporters.
Proceedings of the National Academy of Sciences of the United States of America
Hernando N,Déliot N,Gisler SM,Lederer E,Weinman EJ,Biber J,Murer H
R950-25 was used in western blot to test if role of PDZ-interactions in the localization of Type IIa Na/P(i) cotransporter
Tue Sep 03 00:00:00 EDT 2002
Characterization of the nuclear export signal of polypyrimidine tract-binding protein.
The Journal of biological chemistry
Li B,Yen TS
R950-25 was used in immunocytochemistry to describe the NES of polypyrimidine tract-binding protein
Fri Mar 22 00:00:00 EST 2002
Formation and removal of alpha-synuclein aggregates in cells exposed to mitochondrial inhibitors.
The Journal of biological chemistry
Lee HJ,Shin SY,Choi C,Lee YH,Lee SJ
R950-25 was used in western blot to study the effects of mitochondrial electron-transport chain inhibitors on the aggregation of alpha-synuclein and the formation of Lewy bodies
Fri Feb 15 00:00:00 EST 2002
A novel zinc-regulated human zinc transporter, hZTL1, is localized to the enterocyte apical membrane.
The Journal of biological chemistry
Cragg RA,Christie GR,Phillips SR,Russi RM,Küry S,Mathers JC,Taylor PM,Ford D
R950-25 was used in immunocytochemistry to identify hZTL1 as a human zinc transporter
Fri Jun 21 00:00:00 EDT 2002
Inhibition of glucocorticoid-induced apoptosis in 697 pre-B lymphocytes by the mineralocorticoid receptor N-terminal domain.
The Journal of biological chemistry
Planey SL,Derfoul A,Steplewski A,Robertson NM,Litwack G
R950-25 was used in EMSA, immunoprecipitation, and western blot to study the effect of N-terminal domain of the mineralocorticoid on glucocorticoid-induced apoptosis
Fri Nov 01 00:00:00 EST 2002
Identification of developmentally expressed proteins that functionally interact with Nedd4 ubiquitin ligase.
The Journal of biological chemistry
Murillas R,Simms KS,Hatakeyama S,Weissman AM,Kuehn MR
R950-25 was used in western blot to identify and study NEDD4 binding partners in the mid-gestation embryo
Fri Jan 25 00:00:00 EST 2002
Involvement of DNase gamma in apoptosis associated with myogenic differentiation of C2C12 cells.
The Journal of biological chemistry
Shiokawa D,Kobayashi T,Tanuma S
R950-25 was used in western blot to show that DNase gamma is responsible for DNA fragmentation during apoptosis associated with myogenic differentiation
Fri Aug 23 00:00:00 EDT 2002
Unusual binding properties of the SH3 domain of the yeast actin-binding protein Abp1: structural and functional analysis.
The Journal of biological chemistry
Fazi B,Cope MJ,Douangamath A,Ferracuti S,Schirwitz K,Zucconi A,Drubin DG,Wilmanns M,Cesareni G,Castagnoli L
R950-25 was used in western blot to determine the structure of the Abp1-SH3 domain solved at 1.3-A resolution and investigate important residues for ligand binding
Fri Feb 15 00:00:00 EST 2002
Histone deacetylase inhibitors reduce polyglutamine toxicity.
Proceedings of the National Academy of Sciences of the United States of America
McCampbell A,Taye AA,Whitty L,Penney E,Steffan JS,Fischbeck KH
R950-25 was used in western blot to establish a cell culture system with nuclear-targeted polyglutamine and determine the cellular changes
Tue Dec 18 00:00:00 EST 2001
Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase.
Proceedings of the National Academy of Sciences of the United States of America
Kitazume S,Tachida Y,Oka R,Shirotani K,Saido TC,Hashimoto Y
R950-25 was used in immunocytochemistry and western blot to demonstrate that BACE1 is involved in the proteolytic cleavage of ST6Gal I
Tue Nov 20 00:00:00 EST 2001
OX40 stimulation by gp34/OX40 ligand enhances productive human immunodeficiency virus type 1 infection.
Journal of virology
Takahashi Y,Tanaka Y,Yamashita A,Koyanagi Y,Nakamura M,Yamamoto N
R950-25 was used in flow cytometry to demonstrate that OX40-gp34 interactions stimulate HIV-1 expression
Wed Aug 01 00:00:00 EDT 2001
The membrane-type collectin CL-P1 is a scavenger receptor on vascular endothelial cells.
The Journal of biological chemistry
Ohtani K,Suzuki Y,Eda S,Kawai T,Kase T,Keshi H,Sakai Y,Fukuoh A,Sakamoto T,Itabe H,Suzutani T,Ogasawara M,Yoshida I,Wakamiya N
R950-25 was used in Western Blotting to indicate that collectin placenta 1 has important roles in host defences that are different from those of soluble collectins in innate immunity.
Fri Nov 23 00:00:00 EST 2001
Integrin alpha(v)beta(3)/vitronectin interaction affects expression of the urokinase system in human ovarian cancer cells.
The Journal of biological chemistry
Hapke S,Kessler H,Arroyo de Prada N,Benge A,Schmitt M,Lengyel E,Reuning U
R950-25 was used in Western Blotting to investigate whether the expression levels of urokinase type plasminogen activator, uPA receptor, and plasminogen activator inhibitor type-1 are affected by extracellular matrix/integrin interactions.
Fri Jul 13 00:00:00 EDT 2001
hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response.
Nature
Lee JS,Collins KM,Brown AL,Lee CH,Chung JH
R950-25 was used in immunoprecipitation to investigate the relationship between Cds1 kinase (hCds1/Chk2) and BRCA1 during DNA damage
Thu Mar 09 00:00:00 EST 2000
A chimeric protein containing the N terminus of the adeno-associated virus Rep protein recognizes its target site in an in vivo assay.
Journal of virology
Cathomen T,Collete D,Weitzman MD
R950-25 was used in EMSA and western blot to use chimeric proteins of Rep and determine the oligomerization, DNA binding, and activation of reporter gene expression of these constructs
Wed Mar 01 00:00:00 EST 2000
Characterization of Smad phosphorylation and Smad-receptor interaction.
Methods in molecular biology (Clifton, N.J.)
Mehra A,Attisano L,Wrana JL
R950-25 was used in ELISA, Western Blot, Immunoprecipitation to characterise Smad phosphorylation and Smad-receptor interaction.
Tue Jun 27 00:00:00 EDT 2000
Prevention of acute allograft rejection by antibody targeting of TIRC7, a novel T cell membrane protein.
Immunity
Utku N,Heinemann T,Tullius SG,Bulwin GC,Beinke S,Blumberg RS,Beato F,Randall J,Kojima R,Busconi L,Robertson ES,Schülein R,Volk HD,Milford EL,Gullans SR
R950-25 was used in western blot to study the effect of TIRC7 modulation on T cell helper subsets and kidney allografts
Thu Oct 01 00:00:00 EDT 1998
The putative tumour suppressor EXT1 alters the expression of cell-surface heparan sulfate.
Nature genetics
McCormick C,Leduc Y,Martindale D,Mattison K,Esford LE,Dyer AP,Tufaro F
R950-25 was used in immunocytochemistry to determine the localization and function of wildtype and EXT1 variants
Mon Jun 01 00:00:00 EDT 1998
MFR, a putative receptor mediating the fusion of macrophages.
Molecular and cellular biology
Saginario C,Sterling H,Beckers C,Kobayashi R,Solimena M,Ullu E,Vignery A
R950-25 was used in immunocytochemistry to identify a macrophage fusion receptor
Sun Nov 01 00:00:00 EST 1998
The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog.
Nature
Stone DM,Hynes M,Armanini M,Swanson TA,Gu Q,Johnson RL,Scott MP,Pennica D,Goddard A,Phillips H,Noll M,Hooper JE,de Sauvage F,Rosenthal A
R950-25 was used in immunohistochemistry and immunoprecipitation to discuss Sonic hedgehog interactions with Patched
Thu Nov 14 00:00:00 EST 1996
