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产品信息
PA5-34560
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A 15 amino acid peptide near the carboxy terminus of human N-RAS
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
4° C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2551912
产品详细信息
A suggested positive control is 293 cell lysate.
PA5-34560 can be used with blocking peptide PEP-1603.
靶标信息
NRAS (GTPase NRas) is a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. This protein, which has intrinsic GTPase activity, is activated to a GTP-bound form by a GTPase activating protein and inactivated to a GDP-bound form by a guanine nucleotide-exchange factor. Defects in the gene encoding this protein are a cause of juvenile myelomonocytic leukemia (JMML) and Noonan syndrome 6.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: GTPase NRas; N-ras protein part 4; Neuroblastoma RAS; neuroblastoma RAS viral (v-ras) oncogene homolog; RAS; RASN; Transforming protein N-Ras; v-ras neuroblastoma RAS viral oncogene homolog
基因别名: ALPS4; AV095280; CMNS; HRAS1; N-ras; NCMS; NRAS; NRAS1; NS6
UniProt ID: (Human) P01111, (Rat) Q04970
Entrez Gene ID: (Human) 4893, (Mouse) 18176, (Rat) 24605
MAPK cascade
stimulatory C-type lectin receptor signaling pathway
epidermal growth factor receptor signaling pathway
Ras protein signal transduction
axon guidance
Fc-epsilon receptor signaling pathway
ERBB2 signaling pathway
leukocyte migration
establishment of protein localization to Golgi
regulation of protein phosphorylation
signal transduction
small GTPase mediated signal transduction
regulation of gene expression
positive regulation of fibroblast proliferation
negative regulation of skeletal muscle tissue development
regulation of cell cycle
biological_process
positive regulation of cell proliferation
visual learning
actin cytoskeleton organization
regulation of synaptic transmission, GABAergic
positive regulation of Rac protein signal transduction
negative regulation of neuron apoptotic process
negative regulation of cell differentiation
regulation of long-term neuronal synaptic plasticity
striated muscle cell differentiation
epithelial tube branching involved in lung morphogenesis
