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Invitrogen
N-WASP Monoclonal Antibody (OTI2H5)
高级验证
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
图: 1 / 6
N-WASP Antibody (MA5-27438) in IHC (P)
Immunohistochemistry was performed on paraffin-embedded human spleen tissue. To expose target proteins, heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min. Following antigen retrieval, tissues were probed with a WASL monoclonal antibody (Product # MA5-27438) at a dilution of 1:150.
产品信息
MA5-27438
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
OTI2H5
抗原
Full length human recombinant protein of WASL produced in HEK293T cell
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 1% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2724781
靶标信息
The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. The WASL gene product is a homolog of WAS protein, however, unlike the latter, it is ubiquitously expressed and shows highest expression in neural tissues. It has been shown to bind Cdc42 directly, and induce formation of long actin microspikes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Actin nucleation-promoting factor WASL; DKFZp779G0847; MGC48327; n wasp; N-WASP; Neural Wiskott-Aldrich syndrome protein; Wiskott-Aldrich syndrome-like
基因别名: N-WASP; NWASP; WASL; WASPB
UniProt ID: (Human) O00401
Entrez Gene ID: (Human) 8976
transcription, DNA-templated
regulation of transcription, DNA-templated
protein complex assembly
membrane budding
movement of cell or subcellular component
mitotic nuclear division
actin polymerization or depolymerization
response to bacterium
vesicle organization
vesicle transport along actin filament
regulation of protein localization
cellular protein complex localization
Fc-gamma receptor signaling pathway involved in phagocytosis
ephrin receptor signaling pathway
regulation of nitric-oxide synthase activity
cell division
positive regulation of filopodium assembly
spindle localization
negative regulation of membrane tubulation
positive regulation of clathrin-mediated endocytosis
negative regulation of lymphocyte migration
positive regulation of Arp2/3 complex-mediated actin nucleation
