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产品信息
PA5-20005
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A peptide corresponding to 13 amino acids near the carboxy terminus of human NALP1.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11154346
产品详细信息
A suggested positive control is U937 cell lysate.
PA5-20005 can be used with blocking peptide PEP-0308.
靶标信息
NALP1 is a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: caspase recruitment domain protein 7; Caspase recruitment domain-containing protein 7; Death effector filament-forming ced-4-like apoptosis protein; DKFZp586O1822; nacht; NACHT, leucine rich repeat and PYD (pyrin domain) containing 1; NACHT, leucine rich repeat and PYD containing 1; NACHT, LRR and PYD containing protein 1; NACHT, LRR and PYD domains-containing protein 1; NLR family, pyrin domain containing 1; Nucleotide-binding domain and caspase recruitment domain; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 1
基因别名: CARD7; CIDED; CLR17.1; DEFCAP; DEFCAP-L/S; KIAA0926; NAC; NALP1; NLRP1; PP1044; SLEV1; VAMAS1
UniProt ID: (Human) Q9C000
Entrez Gene ID: (Human) 22861
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
inflammatory response
response to muramyl dipeptide
defense response to bacterium
innate immune response
positive regulation of interleukin-1 beta secretion
regulation of inflammatory response
neuron apoptotic process
