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NBS1 Antibody (PA5-78071) in ICC/IF
NBS1 Polyclonal Antibody detects NBS1 protein at nucleus by immunofluorescent analysis. Sample: A431 cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: NBS1 stained by NBS1 Polyclonal Antibody (Product # PA5-78071) diluted at 1:500. Red: phalloidin, a cytoskeleton marker, diluted at 1:200.
产品信息
PA5-78071
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human NBS1. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2736192
产品详细信息
Positive Control: 293T, NT2D1
Predicted Reactivity: Rhesus Monkey (94%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
The p95 gene (identical to NBS1 and nibrin) is a member of the hMre11/hRad50 double-strand break complex. This protein complex has been implicated in Nijmegen breakage syndrome, an autosomal recessive disorder marked by increased cancer incidence, cell cycle checkpoint deficits, and ionizing radiation sensitivity, thus revealing a direct molecular link between double-strand break repair and cell cycle checkpoint functions.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: AT V1; AT V2; Cell cycle regulatory protein p95; FLJ10155; hNbs1; MGC87362; Nibrin; Nijmegen breakage syndrome 1 (nibrin); Nijmegen breakage syndrome protein 1; OTTHUMP00000204088; p95 protein of the MRE11/RAD50 complex; p95-NBS1
基因别名: AT-V1; AT-V2; ATV; NBN; NBS; NBS1; P95
UniProt ID: (Human) O60934
Entrez Gene ID: (Human) 4683
DNA damage checkpoint
telomere maintenance
double-strand break repair via homologous recombination
DNA double-strand break processing
DNA synthesis involved in DNA repair
strand displacement
blastocyst growth
DNA replication
double-strand break repair
double-strand break repair via nonhomologous end joining
cell cycle arrest
mitotic cell cycle checkpoint
mitotic G2 DNA damage checkpoint
cell proliferation
regulation of DNA-dependent DNA replication initiation
DNA damage response, signal transduction by p53 class mediator
telomeric 3' overhang formation
positive regulation of protein autophosphorylation
positive regulation of telomere maintenance
DNA duplex unwinding
positive regulation of kinase activity
isotype switching
neuromuscular process controlling balance
meiotic cell cycle
intrinsic apoptotic signaling pathway
regulation of signal transduction by p53 class mediator
negative regulation of telomere capping
