Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
NBS1 Monoclonal Antibody (1C3)
高级验证
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
产品信息
MA1-23263
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
1C3
抗原
The complete coding region of the human p95/NBS1 expressed in E. coli.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7, with 20% glycerol
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_560308
产品详细信息
Recommended positive controls: 293T, MCF7, HeLa, Raji.
靶标信息
The p95 gene (identical to NBS1 and nibrin) is a member of the hMre11/hRad50 double-strand break complex. This protein complex has been implicated in Nijmegen breakage syndrome, an autosomal recessive disorder marked by increased cancer incidence, cell cycle checkpoint deficits, and ionizing radiation sensitivity, thus revealing a direct molecular link between double-strand break repair and cell cycle checkpoint functions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: AT V1; AT V2; Cell cycle regulatory protein p95; FLJ10155; hNbs1; MGC87362; Nibrin; Nijmegen breakage syndrome 1 (nibrin); Nijmegen breakage syndrome protein 1; Nijmegen breakage syndrome protein 1 homolog; OTTHUMP00000204088; p95 protein of the MRE11/RAD50 complex; p95-NBS1
基因别名: AT-V1; AT-V2; ATV; NBN; NBS; NBS1; P95
UniProt ID: (Human) O60934, (Mouse) Q9R207
Entrez Gene ID: (Human) 4683, (Mouse) 27354
DNA damage checkpoint
telomere maintenance
double-strand break repair via homologous recombination
DNA double-strand break processing
DNA synthesis involved in DNA repair
strand displacement
blastocyst growth
DNA replication
double-strand break repair
double-strand break repair via nonhomologous end joining
cell cycle arrest
mitotic cell cycle checkpoint
mitotic G2 DNA damage checkpoint
cell proliferation
regulation of DNA-dependent DNA replication initiation
DNA damage response, signal transduction by p53 class mediator
telomeric 3' overhang formation
positive regulation of protein autophosphorylation
positive regulation of telomere maintenance
DNA duplex unwinding
positive regulation of kinase activity
isotype switching
neuromuscular process controlling balance
meiotic cell cycle
intrinsic apoptotic signaling pathway
regulation of signal transduction by p53 class mediator
negative regulation of telomere capping
in utero embryonic development
DNA repair
cellular response to DNA damage stimulus
cell cycle
positive regulation of cell proliferation
negative regulation of neuron differentiation
negative regulation of viral entry into host cell
regulation of fibroblast proliferation
