Invitrogen

NCF2 Polyclonal Antibody

高级验证

This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.

查看其他12个NCF2抗体

说明书

实验方案

技术支持

说明书

实验方案

技术支持

NCF2 Antibody in Immunohistochemistry (IHC)

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NCF2 Antibody (PA5-51702) in IHC

Immunohistochemical staining of NCF2 in human bone marrow and skeletal muscle tissues using NCF2 Polyclonal Antibody (Product # PA5-51702). Corresponding NCF2 RNA-seq data are presented for the same tissues.

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NCF2 Antibody — Relative expression in different tissues in IHC: Detection of differential expression levels of NCF2 demonstrates antibody specificity. Immunohistochemical analysis of NCF2 using anti-NCF2 Polyclonal Antibody (Product # PA5-51702), shows significant staining of NCF2 in human bone marrow and shows minimal or weak staining in human skeletal muscle tissues. The relative expression levels of NCF2 within each tissue is shown using RNA-Seq. {RE}

产品信息

PA5-51702

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.04-0.4 µg/mL

免疫组化 (IHC)

1:200-1:500

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human NCF2. Recombinant protein control fragment (Product #RP-95408).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.05 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2644514

产品详细信息

Immunogen sequence: QEESSPQSDI PAPPSSKAPG RPQLSPGQKQ KEEPKEVKLS VPMPYTLKVH YKYTVVMKTQ PGLPYSQVRD MVSKKLELRL EHTKLSYRPR DSNELVPLSE DSMKDAWGQV KNYCLTLWCE NTVGDQGFPD EPKESEKADA NNQTTEPQ

Highest antigen sequence identity to the following orthologs: Mouse - 76%, Rat - 24%.

靶标信息

NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). Defects in NCF2 are a cause of chronic granulomatous disease autosomal recessive cytochrome-b-positive type 2 (CGD2). Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: 67 kDa neutrophil oxidase factor; chronic granulomatous disease, autosomal 2; FLJ93058; NADPH oxidase activator 2; NCF-2; Neutrophil cytosol factor 2; neutrophil cytosolic factor 2 (65kD, chronic granulomatous disease, autosomal 2); Neutrophil NADPH oxidase factor 2; p67-phox

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基因别名: NCF-2; NCF2; NOXA2; P67-PHOX; P67PHOX

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UniProt ID: (Human) P19878

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Entrez Gene ID: (Human) 4688

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功能

protein binding protein C-terminus binding electron carrier activity superoxide-generating NADPH oxidase activity Rac GTPase binding protein-binding activity modulator

参与通路

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent superoxide metabolic process cellular defense response superoxide anion generation innate immune response cell redox homeostasis respiratory burst vascular endothelial growth factor receptor signaling pathway oxidation-reduction process