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The NCK family of SH2/SH3 adaptor proteins consists of two members, NCK1 and NCK2, which couple tyrosine kinase signaling, including the EGF and PDGF receptor-pathways, to downstream signaling proteins. The NCK2 protein binds human PDGFR-b (Tyr-1009); overexpression of NCK2 inhibits PDGF-induced membrane ruffling and lamellipod formation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Cytoplasmic protein NCK2; Growth factor receptor-bound protein 4; NCK adaptor protein 2; Nck-2; noncatalytic region of tyrosine kinase, beta; SH2/SH3 adaptor protein NCK-beta
基因别名: 4833426I10Rik; GRB4; Nck-2; NCK2; NCKbeta
UniProt ID: (Human) O43639, (Mouse) O55033
Entrez Gene ID: (Human) 8440, (Mouse) 17974
分子生物学功能:
scaffold/adaptor protein