Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
产品信息
H00023054-M01
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
2D7
抗原
NCOA6 (NP_054790, 1954 a.a. approximately 2063 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
Product may be used with Western Blot (Cell lysate).
Immunogen sequence: VGSHPELLPS IAPSQNLVSK ETSTTALQAS VARPELEVNA AIVSGQSSEP KEIVEKSKIP GRRNSRTEEP TVASESVENG HRKRSSRPAS ASSSTKDITS AVQSKRRKSK
靶标信息
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: Activating signal cointegrator 2; activating signal cointegrator-2; Amplified in breast cancer protein 3; amplified in breast cancer-3 protein; ASC-2; Cancer-amplified transcriptional coactivator ASC-2; NRC RAP250; Nuclear receptor coactivator 6; Nuclear receptor coactivator RAP250; Nuclear receptor-activating protein, 250 kDa; peroxisome proliferator-activated receptor interacting protein; Peroxisome proliferator-activated receptor-interacting protein; PPAR-interacting protein; thyroid hormone receptor binding protein; Thyroid hormone receptor-binding protein
基因别名: AIB3; ASC2; KIAA0181; NCOA6; NRC; PRIP; RAP250; TRBP
UniProt ID: (Human) Q14686
Entrez Gene ID: (Human) 23054
chromatin binding
transcription coactivator activity
protein binding
ligand-dependent nuclear receptor binding
enzyme binding
protein domain specific binding
estrogen receptor binding
ligand-dependent nuclear receptor transcription coactivator activity
glucocorticoid receptor binding
protein homodimerization activity
peroxisome proliferator activated receptor binding
retinoid X receptor binding
thyroid hormone receptor binding
chromatin/chromatin-binding, or -regulatory protein
ovarian follicle development
DNA replication
DNA repair
DNA recombination
DNA-templated transcription, initiation
transcription initiation from RNA polymerase II promoter
cellular response to DNA damage stimulus
brain development
heart development
response to hormone
myeloid cell differentiation
intracellular estrogen receptor signaling pathway
positive regulation of insulin secretion involved in cellular response to glucose stimulus
glucocorticoid receptor signaling pathway
cellular lipid metabolic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
