NeoBiotechnologies

NEUROG3/Neurogenin 3/NGN3 (Transcription Factor) Monoclonal Antibody (NGN3/1808)

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NEUROG3/Neurogenin 3/NGN3 (Transcription Factor) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

NEUROG3/Neurogenin 3/NGN3 (Transcription Factor) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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NEUROG3/Neurogenin 3/NGN3 (Transcription Factor) Antibody (50674-MSM1-P1ABX) in IHC (P)

Formalin-fixed, paraffin-embedded human tonsil stained with NEUROG3 Mouse Monoclonal Antibody (NGN3/1808) HIER: Tris/EDTA, pH9.0, 45 min. 2°C: HRP-polymer, 30 min. DAB, 5 min.

NEUROG3/Neurogenin 3/NGN3 (Transcription Factor) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

NEUROG3/Neurogenin 3/NGN3 (Transcription Factor) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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NEUROG3/Neurogenin 3/NGN3 (Transcription Factor) Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Formalin-fixed, paraffin-embedded human tonsil stained with NEUROG3 Mouse Monoclonal Antibody (NGN3/1808) HIER: Tris/EDTA, pH9.0, 45 min. 2°C: HRP-polymer, 30 min. DAB, 5 min.

NEUROG3/Neurogenin 3/NGN3 (Transcription Factor) Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Formalin-fixed, paraffin-embedded human brain stained with NEUROG3 Mouse Monoclonal Antibody (NGN3/1808) Inset: PBS instead of primary antibody; secondary only negative control.

产品信息

50674-MSM1-P1ABX

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

1-2 µg/mL

-

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG2b, kappa

分类

Monoclonal

类型

Antibody

克隆号

NGN3/1808

抗原

Recombinant fragment (around aa1-200) of human NEUROG3 protein.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A/G

保存液

PBS

内含物

no preservative

保存条件

-20°C or -80°C if preferred

运输条件

Ambient (domestic); Dry ice (international)

产品详细信息

Positive Control: colon HeLa cells. Human fetal gut liver or heart.

Cellular Location: Nucleus.

靶标信息

Neurog 3 protein contains one basic helix-loop-helix (bHLH) domain.It is both necessary and sufficient to induce endocrine islet cell differentiation from embryonic pancreatic progenitors. Not only does itinitiates endocrine cell differentiation, italso promotes islet cell maturation and maintains islet function. It is reported that Neurogenin 3 can redirect the differentiation of bipotential secretory progenitors to endocrine rather than goblet cell fate.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: bHLHa7; Class A basic helix-loop-helix protein 7; Neurogenin-3; neurogenin3; NGN-3; Protein atonal homolog 5

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基因别名: ATOH5; BHLHA7; Math4B; NEUROG3; NGN-3; NGN3

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UniProt ID: (Human) Q9Y4Z2

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Entrez Gene ID: (Human) 50674

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RNA polymerase II core promoter proximal region sequence-specific DNA binding core promoter binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding transcription coactivator activity protein binding chromatin DNA binding protein dimerization activity basic helix-loop-helix transcription factor

参与通路

negative regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter nervous system development central nervous system development peripheral nervous system development spinal cord development epithelial cell differentiation forebrain development hindbrain development endocrine pancreas development positive regulation of neuron differentiation positive regulation of transcription from RNA polymerase II promoter regulation of dendrite morphogenesis positive regulation of sequence-specific DNA binding transcription factor activity transdifferentiation