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产品信息
MA1-10441
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Pig,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
NF-05
抗原
Pig brain neurofilament protein-enriched fraction after depolymerization of microtubules
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
sequential chromatography
保存液
PBS, pH 7.4
内含物
15mM sodium azide
保存条件
4° C, do not freeze
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11157665
产品详细信息
This antibody recognizes a nonphosphorylated epitope of neurofilament heavy protein (NF-H), a 210 kDa intracellular structural protein of Intermediate Filament Proteins family. NF-H is mainly expressed in the central and peripheral nervous system and reproductive system and is biochemically very stable. It will not cross-react with mouse.
靶标信息
Involved in the maintenance of neuronal caliber, neurofilaments are the intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H. Like most other intermediate filament proteins (IFPs), the expression of the different neuronal IFPs is both tissue-specific and developmentally regulated. NF-H has an important role in mature axons and is involved in amyotrophic lateral sclerosis (ALS).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 200 kDa neurofilament protein; NEF3; neurofilament; Neurofilament heavy polypeptide; Neurofilament triplet H protein; neurofilament, heavy polypeptide 200kDa; NF 200 kD; NF-H; NHC
基因别名: CMT2CC; KIAA0845; NEFH; NF-H; NFH
UniProt ID: (Human) P12036
Entrez Gene ID: (Human) 4744, (Pig) 100156492, (Rat) 24587
microtubule cytoskeleton organization
ovarian follicle atresia
axonogenesis
spinal cord development
hippocampus development
cerebral cortex development
cell projection assembly
axon regeneration
neurofilament bundle assembly
cellular response to oxidative stress
response to cocaine
peripheral nervous system neuron axonogenesis
axon development
cellular response to estradiol stimulus
regulation of organelle transport along microtubule
response to sodium arsenite
response to acrylamide
brain development
embryo development
neuron projection development
intermediate filament cytoskeleton organization
intermediate filament bundle assembly
neurofilament cytoskeleton organization
