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产品信息
OMA1-06115
应用
建议稀释比
已发表文章
产品规格
种属反应
Bovine,
Dog,
Chicken,
Guinea pig,
Human,
Mouse,
Non-human primate,
Sheep,
Rabbit,
Rat,
Xenopus
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
RNF 404
抗原
Neurofilament preparation of calf brain tissue
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
purified
保存液
PBS
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_325536
产品详细信息
OMA1-06115 specifically detects the phosphorylated 200 kDa neurofilament from Human, Bovine, Canine, Chicken, Guinea Pig, Non-human primate, mouse, Rabbit, Rat, Ovine and Xenopus tissues.
OMA1-06115 has been successfully used in Western blot, IHC (F), and IHC (P) procedures. By Western blot, this antibody detects an ~200 kDa protein representing the phosphorylated form of the 200 kDa neurofilament from human brain homogenate.
OMA1-06115 antigen is cytoskeletal preparation of calf brain tissue.
靶标信息
Involved in the maintenance of neuronal caliber, neurofilaments are the intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H. Like most other intermediate filament proteins (IFPs), the expression of the different neuronal IFPs is both tissue-specific and developmentally regulated. NF-H has an important role in mature axons and is involved in amyotrophic lateral sclerosis (ALS).
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生物信息学
蛋白别名: 200 kDa neurofilament protein; heavy neurofilament protein; intermediate filament protein; NEF3; neurofilament; neurofilament 200kDa; Neurofilament heavy polypeptide; Neurofilament triplet H protein; neurofilament, heavy polypeptide 200kDa; neurofilament, heavy polypeptide L homeolog; neurofilament-H; NF 200 kD; NF-H; NHC
基因别名: CMT2CC; KIAA0845; mKIAA0845; NEFH; NF-H; NF200; NFH; XELAEV_18007418mg
UniProt ID: (Human) P12036, (Mouse) P19246
microtubule cytoskeleton organization
ovarian follicle atresia
axonogenesis
spinal cord development
hippocampus development
cerebral cortex development
cell projection assembly
axon regeneration
neurofilament bundle assembly
cellular response to oxidative stress
response to cocaine
peripheral nervous system neuron axonogenesis
axon development
cellular response to estradiol stimulus
regulation of organelle transport along microtubule
response to sodium arsenite
response to acrylamide
brain development
embryo development
neuron projection development
intermediate filament cytoskeleton organization
intermediate filament bundle assembly
neurofilament cytoskeleton organization
