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Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: brain-enriched SH3-domain protein Besh3; Eph-interacting exchange protein; Ephexin-1; Neuronal guanine nucleotide exchange factor
基因别名: ARHGEF27; Besh3; EPHEXIN; NGEF
UniProt ID: (Human) Q8N5V2
Entrez Gene ID: (Human) 25791, (Rat) 246217
分子生物学功能:
guanyl-nucleotide exchange factor