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NGFR Antibody (MA5-29736) in WB
Western Blot using NGFR Recombinant Rabbit Monoclonal Antibody (117) (Product # MA5-29736) at 1:500. Lane A: Rat Brain Tissue lysate, Lane B: Mouse Brain Tissue lysate, Lane C: Mouse Heart Tissue lysate. Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG H&L (DyLight™ 800) at 1:10,000 dilution. Developed using the Odyssey technique. Performed under reducing conditions. Predicted band size: 45 kDa. Observed band size: 51 kDa. (We are unsure of the identity of these extra bands).
产品信息
MA5-29736
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
117
抗原
Recombinant Mouse NGFR/P75 Protein (Met1-Asn243)
偶联物
形式
Liquid
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2785559
产品详细信息
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
This antibody has specificity for Mouse NGFR/P75.
靶标信息
Neurotrophic factors control the survival, differentiation and maintenance of neurons in the peripheral and central nervous systems, and of other neural crest-derived cell types. Developing sympathetic neurons are absolutely dependent upon nerve growth factor (NGF) during the period of target competition in vivo. Antibodies reacting specifically with NGFR p75 are useful tools in the detection and characterization of NGFR p75, to enhance our understanding of a wide range of phenomena in the development, plasticity and repair of the nervous system.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD271; CD271 antigen; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; Low-affinity nerve growth factor receptor p75NGFR; Low-affinity nerve growth factor receptor p75NGR; NGF receptor; p-75; p75 neurotrophin receptor; p75 ntr; TNR16; Tumor necrosis factor receptor superfamily member 16
基因别名: LNGFR; Ngfr; p75; p75NGFR; p75NTR; Tnfrsf16
UniProt ID: (Mouse) Q9Z0W1
Entrez Gene ID: (Mouse) 18053
intracellular protein transport
apoptotic process
signal transduction
multicellular organism development
nervous system development
axon guidance
central nervous system development
response to wounding
regulation of gene expression
positive regulation of cell death
negative regulation of neuron projection development
programmed cell death
detection of temperature stimulus
sensory perception of pain
nerve development
cell differentiation
hair follicle morphogenesis
positive regulation of myelination
positive regulation of synaptic transmission, cholinergic
circadian regulation of gene expression
cellular response to oxidative stress
positive regulation of Rho protein signal transduction
negative regulation of fibroblast growth factor receptor signaling pathway
positive regulation of odontogenesis of dentin-containing tooth
glucose homeostasis
positive regulation of apoptotic process
positive regulation of MAPK cascade
negative regulation of neuron apoptotic process
skin development
positive regulation of fibroblast proliferation
rhythmic process
negative regulation of hair follicle development
positive regulation of protein kinase B signaling
negative regulation of mitochondrial depolarization
positive regulation of synaptic transmission, glutamatergic
negative regulation of cell death
positive regulation of neuron death
regulation of reactive oxygen species metabolic process
positive regulation of apoptotic signaling pathway
regulation of glucose import in response to insulin stimulus
