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NGFR Antibody (MA1-18418) in ICC/IF
Nature 2018 -
Extended Data Figure 4: Validation of novel lineages in mouse and human by immunofluorescence. a , Immunofluorescence in mouse tracheal epithelium for Krt4 (green, arrowheads), Krt5 (basal), Krt8 (luminal), Scgb1a1 (club, secretory) and Foxj1 (ciliated) (n=3 animals). b , Immunofluorescence in differentiated HBEC cultures for FOXN4 (red, arrows), FOXJ1 (arrowheads mark FOXJ1 low cells) and Acetylated alpha... View More
产品信息
MA1-18418
应用
建议稀释比
已发表文章
产品规格
种属反应
Dog,
Cat,
Human,
Sheep,
Pig,
Rabbit
已发表种属
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
ME20.4
抗原
Human WM245 melanoma cells.
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_10983110
产品详细信息
Reconstitute with the addition of 100 µL of sterile water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20 °C for a higher stability, and at 4 °C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
靶标信息
Neurotrophic factors control the survival, differentiation and maintenance of neurons in the peripheral and central nervous systems, and of other neural crest-derived cell types. Developing sympathetic neurons are absolutely dependent upon nerve growth factor (NGF) during the period of target competition in vivo. Antibodies reacting specifically with NGFR p75 are useful tools in the detection and characterization of NGFR p75, to enhance our understanding of a wide range of phenomena in the development, plasticity and repair of the nervous system.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: CD271; CD271 antigen; Gp80-LNGFR; low affinity nerve growth factor receptor; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; Low-affinity nerve growth factor receptor p75NGFR; Low-affinity nerve growth factor receptor p75NGR; nerve growth factor receptor (TNFR superfamily, member 16); NGF receptor; p-75; p75 ICD; p75 ntr; TNFR superfamily, member 16; TNR16; Tumor necrosis factor receptor superfamily member 16
基因别名: CD271; Gp80-LNGFR; NGFR; NGR; p75(NTR); p75NTR; TNFRSF16
UniProt ID: (Human) P08138
Entrez Gene ID: (Pig) 100525607, (Sheep) 101119064, (Dog) 491071, (Human) 4804, (Rabbit) 100349095
beta-amyloid binding
signal transducer activity
receptor activity
transmembrane signaling receptor activity
tumor necrosis factor-activated receptor activity
neurotrophin TRKA receptor binding
protein binding
Rab GTPase binding
ubiquitin protein ligase binding
nerve growth factor binding
preprotein binding
transmembrane signal receptor
intracellular protein transport
activation of cysteine-type endopeptidase activity involved in apoptotic process
inflammatory response
immune response
axon guidance
response to wounding
negative regulation of neuron projection development
sensory perception of pain
membrane protein intracellular domain proteolysis
positive regulation of myelination
positive regulation of synaptic transmission, cholinergic
response to lipopolysaccharide
circadian regulation of gene expression
tumor necrosis factor-mediated signaling pathway
cellular response to oxidative stress
positive regulation of Rho protein signal transduction
skeletal muscle cell differentiation
regulation of cell proliferation
glucose homeostasis
regulation of apoptotic process
positive regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of MAPK cascade
negative regulation of neuron apoptotic process
neurotrophin TRK receptor signaling pathway
negative regulation of axonogenesis
positive regulation of axonogenesis
positive regulation of protein kinase B signaling
negative regulation of mitochondrial depolarization
positive regulation of synaptic transmission, glutamatergic
apoptotic signaling pathway
positive regulation of neuron death
regulation of reactive oxygen species metabolic process
regulation of glucose import in response to insulin stimulus
