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Immunogen sequence: KFSVEEYLVH ALQGSVSSGQ AHSLTSLAKT WAARGSRSRE PSPKTEDNEG VLLTEKLKPV DYEYREEVHW ATHQLRLGRG SFGEVHRMED KQTGFQCAVK KVRLEVFRAE ELMACAGLTS PRIVPLYGAV REGPWVNIFM ELLEGGSLGQ LVKEQGCLPE DRALYYLGQA LEGLEYLHSR RILHGDVKAD NVLLSSDGSH AALCDFGHAV CLQPDGLGKS LLTGDYIPGT ETHMAPEVVL GRSCDAKVDV WSSCCMMLHM LNGCHPWTQF FRGPLCLKIA SEPPPVREIP PSCAPLTAQA IQEGLRKEPI HRVSAAELGG KVNRALQQVG GLK
Positive Samples: Raji; Cellular Location: Cytoplasm
MAP3K14 (NIK) is structurally related to MAP3Ks. MAP3K14 phosphorylates and activates CHUK (IKKalpha) and IKBKB (IKK beta), which in turn phosphorylate IkB-alpha, releasing NF-KappaB leading to up-regulation of inflammatory response genes. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: mitogen-activated protein kinase kinase kinase 14
Entrez Gene ID: (Rat) 360640