Invitrogen

NMDAR2A Polyclonal Antibody

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NMDAR2A Antibody (480031) in WB

Western blot of NMDAR2A in rat hippocampal lysate (10 µg) using a NMDAR2A polyclonal antibody (Product # 480031) showing specific immunolabeling of a ~180 kDa band corresponding to NR2A subunit.

NMDAR2A Antibody in Immunocytochemistry (ICC/IF)

NMDAR2A Antibody in Immunocytochemistry, Immunoprecipitation (ICC/IF, IP)

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产品信息

480031

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000

查看5篇已发表文章 5篇已发表文章

免疫细胞化学 (ICC/IF)

1:500

查看4篇已发表文章 4篇已发表文章

免疫沉淀 (IP)

查看1篇已发表文章 1篇已发表文章

其他PubMed (Misc)

查看1篇已发表文章 1篇已发表文章

产品规格

种属反应

Mouse, Rat

已发表种属

Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide corresponding from the N-terminus of the NR2A subunit of rat NMDA receptor conjugated to KLH.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.25 mg/mL

纯化类型

Affinity chromatography

保存液

0.01M HEPES, pH 7.5, with 0.15M NaCl, 50% glycerol, 100µg/mL BSA

内含物

no preservative

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2532251

靶标信息

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate-gated ion channels. These receptors have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C) and NMDAR2D (GRIN2D). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Borna disease virus docks on neuronal DNA double-strand breaks to replicate and dampens neuronal activity.

iScience

Marty FH,Bettamin L,Thouard A,Bourgade K,Allart S,Larrieu G,Malnou CE,Gonzalez-Dunia D,Suberbielle E

480031 was used in Immunocytochemistry to decipher the interplay between Borna disease virus-1 infection and double-strand breaks, and to unravel its consequences on viral replication and neuronal function.

Fri Jan 21 00:00:00 EST 2022

Borna disease virus docks on neuronal DNA double-strand breaks to replicate and dampens neuronal activity.

iScience

Marty FH,Bettamin L,Thouard A,Bourgade K,Allart S,Larrieu G,Malnou CE,Gonzalez-Dunia D,Suberbielle E

Fri Jan 21 00:00:00 EST 2022

Rabphilin-3A Drives Structural Modifications of Dendritic Spines Induced by Long-Term Potentiation.

Cells

Franchini L,Stanic J,Barzasi M,Zianni E,Mauceri D,Diluca M,Gardoni F

480031 was used in Immunocytochemistry to demonstrate a key role for Rph3A in the modulation of structural synaptic plasticity at hippocampal synapses that correlates with its interactions with both NMDARs and AMPARs.

Wed May 11 00:00:00 EDT 2022

Rabphilin-3A Drives Structural Modifications of Dendritic Spines Induced by Long-Term Potentiation.

Cells

Franchini L,Stanic J,Barzasi M,Zianni E,Mauceri D,Diluca M,Gardoni F

Wed May 11 00:00:00 EDT 2022

Intravitreal injection of peptides PnPa11 and PnPa13, derivatives of Phoneutria nigriventer spider venom, prevents retinal damage.

The journal of venomous animals and toxins including tropical diseases

Dourado LFN,da Silva FR,Toledo CR,da Silva CN,Santana CP,da Costa BL,de Lima ME,Cunha ADS

480031 was used in Western Blotting to evaluate the safety of intravitreal use and the neuroprotective effect of these peptides.

Sun Apr 17 00:00:00 EDT 2022

Intravitreal injection of peptides PnPa11 and PnPa13, derivatives of Phoneutria nigriventer spider venom, prevents retinal damage.

The journal of venomous animals and toxins including tropical diseases

Dourado LFN,da Silva FR,Toledo CR,da Silva CN,Santana CP,da Costa BL,de Lima ME,Cunha ADS

480031 was used in Western Blotting to evaluate the safety of intravitreal use and the neuroprotective effect of these peptides.

Sun Apr 17 00:00:00 EDT 2022

X11 and X11-like proteins regulate the level of extrasynaptic glutamate receptors.

Journal of neurochemistry

Motodate R,Saito H,Sobu Y,Hata S,Saito Y,Nakaya T,Suzuki T

480031 was used in Western Blotting to investigate if X11/Mint 1 and X11-like (X11L)/Mint 2 regulate the glutamate receptor micro-localization to the extrasynaptic region.

Fri Feb 01 00:00:00 EST 2019

Linking NMDA Receptor Synaptic Retention to Synaptic Plasticity and Cognition.

iScience

Franchini L,Stanic J,Ponzoni L,Mellone M,Carrano N,Musardo S,Zianni E,Olivero G,Marcello E,Pittaluga A,Sala M,Bellone C,Racca C,Di Luca M,Gardoni F

480031 was used in Immunocytochemistry to induce synaptic plasticity in the presence or absence of agents modulating Rph3A function.

Fri Sep 27 00:00:00 EDT 2019

The Developmental Shift of NMDA Receptor Composition Proceeds Independently of GluN2 Subunit-Specific GluN2 C-Terminal Sequences.

Cell reports

McKay S,Ryan TJ,McQueen J,Indersmitten T,Marwick KFM,Hasel P,Kopanitsa MV,Baxter PS,Martel MA,Kind PC,Wyllie DJA,O'Dell TJ,Grant SGN,Hardingham GE,Komiyama NH

Published figure using NMDAR2A polyclonal antibody (Product # 480031) in Western Blot

Tue Oct 23 00:00:00 EDT 2018

A de novo t(10;19)(q22.3;q13.33) leads to ZMIZ1/PRR12 reciprocal fusion transcripts in a girl with intellectual disability and neuropsychiatric alterations.

Neurogenetics

Córdova-Fletes C,Domínguez MG,Delint-Ramirez I,Martínez-Rodríguez HG,Rivas-Estilla AM,Barros-Núñez P,Ortiz-López R,Neira VA

480031 was used in western blot to study translocated genes, MIZ-type containing 1 and proline-rich 12.

Thu Oct 01 00:00:00 EDT 2015

Rabphilin 3A retains NMDA receptors at synaptic sites through interaction with GluN2A/PSD-95 complex.

Nature communications

Stanic J,Carta M,Eberini I,Pelucchi S,Marcello E,Genazzani AA,Racca C,Mulle C,Di Luca M,Gardoni F

480031 was used in immunocytochemistry to assess how rabphilin 3A retains NMDA receptors through interaction with GluN2A/PSD-95 complex synapse sites

Fri Dec 18 00:00:00 EST 2015

Rabphilin 3A retains NMDA receptors at synaptic sites through interaction with GluN2A/PSD-95 complex.

Nature communications

Stanic J,Carta M,Eberini I,Pelucchi S,Marcello E,Genazzani AA,Racca C,Mulle C,Di Luca M,Gardoni F

480031 was used in immunocytochemistry to assess how rabphilin 3A retains NMDA receptors through interaction with GluN2A/PSD-95 complex synapse sites

Fri Dec 18 00:00:00 EST 2015

Rabphilin 3A retains NMDA receptors at synaptic sites through interaction with GluN2A/PSD-95 complex.

Nature communications

Stanic J,Carta M,Eberini I,Pelucchi S,Marcello E,Genazzani AA,Racca C,Mulle C,Di Luca M,Gardoni F

480031 was used in immunocytochemistry to assess how rabphilin 3A retains NMDA receptors through interaction with GluN2A/PSD-95 complex synapse sites

Fri Dec 18 00:00:00 EST 2015

Amino terminal domains of the NMDA receptor are organized as local heterodimers.

PloS one

Lee CH,Gouaux E

480031 was used in western blot to report the dimer-of-heterodimer arrangement of the GluN1/GluN2A and GluN1/GluN2B NMDA receptors.

Fri Apr 22 00:00:00 EDT 2011

生物信息学

蛋白别名: GluN2A; GluRepsilon1; Glutamate [NMDA] receptor subunit epsilon-1; glutamate receptor; Glutamate receptor ionotropic, NMDA 2A; hNR2A; N-methyl D-aspartate receptor subtype 2A; N-methyl-D-aspartate receptor subunit 2A; NMDA Receptor 2A; NMDAR 2A; NMDAR2A; OTTHUMP00000160135; OTTHUMP00000174531

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基因别名: GluN2A; Grin2a; NMDAR2A; NR2A

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UniProt ID: (Mouse) P35436, (Rat) Q00959

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Entrez Gene ID: (Mouse) 14811, (Rat) 24409

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功能