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NMDAR2A (GluN2A) (extracellular) Antibody (AGC-002-200UL) in ICC/IF
Expression of NR2A in rat C6 glioma cells - Cell surface detection of NR2A in live intact rat C6 glioma cells. A. Cells werestained with Anti-NMDAR2A (GluN2A) (extracellular) Antibody (#AGC-002), (1:100), followed by goat Anti-rabbit-AlexaFluor-555 secondary Antibody (red). Cell nuclei were stained with the cell permeable dye Hoechst 33342 (blue staining). B. Live view of the same field.
产品信息
AGC-002-200UL
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
GHSHDVTERELRN(C), corresponding to amino acid residues 41-53 of rat NR2A, Extracellular, N-terminus
偶联物
形式
Lyophilized
浓度
0.55 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate-gated ion channels. These receptors have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C) and NMDAR2D (GRIN2D). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GluN2A; GluRepsilon1; Glutamate [NMDA] receptor subunit epsilon-1; glutamate receptor; Glutamate receptor ionotropic, NMDA 2A; glutamate receptor, ionotropic, N-methyl D-aspartate 2A; hNR2A; N-methyl D-aspartate receptor subtype 2A; N-methyl-D-aspartate receptor channel, subunit epsilon-1; N-methyl-D-aspartate receptor subunit 2A; NMDA Receptor 2A; NMDAR 2A; NMDAR2A; OTTHUMP00000160135; OTTHUMP00000174531
基因别名: EPND; FESD; GluN2A; GRIN2A; LKS; NMDAR2A; NR2A
UniProt ID: (Human) Q12879, (Mouse) P35436, (Rat) Q00959
Entrez Gene ID: (Human) 2903, (Mouse) 14811, (Rat) 24409
NMDA glutamate receptor activity
Ras guanyl-nucleotide exchange factor activity
extracellular-glutamate-gated ion channel activity
calcium channel activity
protein binding
zinc ion binding
receptor activity
ionotropic glutamate receptor activity
receptor binding
ion channel activity
cation channel activity
glutamate binding
protein kinase binding
voltage-gated cation channel activity
protein complex binding
glutamate receptor binding
neurotransmitter binding
metal ion binding
protein heterodimerization activity
protein dimerization activity
cell adhesion molecule binding
ATPase binding
scaffold protein binding
transmembrane signal receptor
MAPK cascade
startle response
response to amphetamine
transport
glutamate receptor signaling pathway
chemical synaptic transmission
learning or memory
memory
protein localization
visual learning
response to wounding
sensory perception of pain
neurogenesis
sleep
directional locomotion
ionotropic glutamate receptor signaling pathway
negative regulation of protein catabolic process
dopamine metabolic process
serotonin metabolic process
response to drug
positive regulation of apoptotic process
positive regulation of GTPase activity
response to ethanol
regulation of sensory perception of pain
excitatory postsynaptic potential
long-term synaptic potentiation
calcium ion transmembrane transport
positive regulation of long-term synaptic potentiation
action potential
ion transport
cation transport
calcium ion transport
learning
locomotory behavior
positive regulation of cell death
ion transmembrane transport
regulation of ion transmembrane transport
synaptic transmission, glutamatergic
locomotion
regulation of membrane potential
regulation of synaptic plasticity
regulation of long-term neuronal synaptic plasticity
rhythmic process
modulation of synaptic transmission
detection of mechanical stimulus involved in sensory perception of pain
protein tetramerization
regulation of postsynaptic membrane potential
cellular response to amino acid stimulus
cellular response to zinc ion
cation transmembrane transport
positive regulation of excitatory postsynaptic potential
response to light stimulus
response to carbohydrate
response to manganese ion
response to organic cyclic compound
response to amine
spinal cord development
hippocampus development
cerebral cortex development
response to cocaine
response to calcium ion
response to methylmercury
response to other organism
response to ammonium ion
response to fungicide
cellular response to magnesium ion
cellular response to manganese ion
cellular response to dsRNA
cellular response to growth factor stimulus
cellular response to lipid
