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Product Details
PA5-21017
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
An 18 amino acid peptide near the amino terminus of human NOD4.
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11157439
Product Specific Information
A suggested positive control is EL4 cell lysate.
PA5-21017 can be used with blocking peptide PEP-1131.
Target Information
NOD4 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD4 contains a CARD-like domain, a central NOD domain and a large LRR region. NOD4, an IFN-gamma-inducible nuclear protein, plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms. As a key negative regulator of NF-kappa-B and type I interferon signaling, NOD4 may be a useful target for manipulating immune responses against infectious or inflammation-associated diseases, including cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Caterpiller protein 16.1; CLR16.1; NLR family, CARD domain containing 5; NOD-like receptor C5; Nucleotide-binding oligomerization domain protein 27; Nucleotide-binding oligomerization domain protein 4; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 5; nucleotide-binding oligomerization domains 27; Protein NLRC5
Gene Aliases: AI451557; AK220210; CLR16.1; NLRC5; NOD27; NOD4
UniProt ID: (Human) Q86WI3, (Mouse) C3VPR6
Entrez Gene ID: (Human) 84166, (Mouse) 434341
negative regulation of NF-kappaB transcription factor activity
negative regulation of type I interferon production
regulation of kinase activity
innate immune response
positive regulation of MHC class I biosynthetic process
positive regulation of transcription from RNA polymerase II promoter
defense response to virus
positive regulation of interferon-gamma-mediated signaling pathway
negative regulation of type I interferon-mediated signaling pathway
positive regulation of type I interferon-mediated signaling pathway
immune system process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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