Abnova

NODAL Monoclonal Antibody (4D8)

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产品信息

H00004838-M06

应用

建议稀释比

已发表文章

酶联免疫吸附实验 (ELISA)

10 µg/mL

-

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG2a, kappa

分类

Monoclonal

类型

Antibody

克隆号

4D8

抗原

NODAL (NP_060525.3, 180 a.a. approximately 279 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

See Label

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4

内含物

no preservative

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Sequence of this protein is as follows: CWPRPPTPPA TNVLLMLYSN LSQEQRQLGG STLLWEAESS WRAQEGQLSW EWGKRHRRHH LPDRSQLCRK VKFQVDFNLI GWGSWIIYPK QYNAYRCEGE

靶标信息

NODAL is an important TGF-beta family protein in cellular differentiation. While constitutively expressed in many developing tissues, NODAL is problematically associated with the differentiation and development of many cancers. The expression of NODAL is regulated by a Notch signaling pathway, which when disrupted contributes to the aggressive behavior of metastatic cancer cells, particularly in melanoma. The abundance of NODAL expression in melanoma can help determine the stage of cancer and metastatic type/progression when tested in IHC. NODAL interactions with Cripto also predispose toward tumor progression. Overexpression of NODAL is also associated with preeclamptic placenta.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: MGC138230; Nodal homolog

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基因别名: HTX5; NODAL

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UniProt ID: (Human) Q96S42

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Entrez Gene ID: (Human) 4838

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cytokine activity transforming growth factor beta receptor binding growth factor activity morphogen activity receptor agonist activity type I activin receptor binding growth factor

参与通路

negative regulation of transcription from RNA polymerase II promoter trophectodermal cellular morphogenesis neural fold formation liver development placenta development embryonic placenta development maternal placenta development vasculature development heart looping inhibition of neuroepithelial cell differentiation brain development embryonic pattern specification polarity specification of proximal/distal axis regulation of gastrulation positive regulation of vascular endothelial growth factor production negative regulation of cell development positive regulation of pathway-restricted SMAD protein phosphorylation stem cell population maintenance positive regulation of cell-cell adhesion BMP signaling pathway positive regulation of activin receptor signaling pathway floor plate morphogenesis endodermal cell differentiation cell migration involved in gastrulation positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter axial mesodermal cell fate specification mesendoderm development digestive tract morphogenesis embryonic cranial skeleton morphogenesis formation of anatomical boundary positive regulation of epithelial cell proliferation positive regulation of sequence-specific DNA binding transcription factor activity embryonic process involved in female pregnancy maternal process involved in parturition positive regulation of SMAD protein import into nucleus SMAD protein signal transduction left lung morphogenesis negative regulation of androgen receptor signaling pathway epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification positive regulation of ERK1 and ERK2 cascade transforming growth factor beta receptor signaling pathway involved in primitive streak formation nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry negative regulation of trophoblast cell migration negative regulation of chorionic trophoblast cell proliferation regulation of stem cell population maintenance