Invitrogen

NPC1 Polyclonal Antibody

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NPC1 Antibody (PA5-142582) in WB

Western Blot analysis of NPC1 in HEK293 lysate (35 µg protein in RIPA buffer) using NPC1 Polyclonal Antibody (Product # PA5-142582) at 0.5 µg/mL incubated for 1 hour. Detected by chemiluminescence.

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产品信息

PA5-142582

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.5-1.5 µg/mL

产品规格

种属反应

Human

宿主/亚型

Goat / IgG

分类

Polyclonal

类型

Antibody

抗原

Peptide with sequence C-TYHTVLQTSADFID.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Ammonium sulfate precipitation

保存液

TBS, pH 7.3, with 0.5% BSA

内含物

0.02% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

RRID

AB_2933228

产品详细信息

This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:128,000.

靶标信息

Mutations in the Niemann-Pick disease type C1 (NPC1) gene result in a fatal progressive neurodegenerative disorder characterized by an abnormal sequestration of lipids including cholesterol and glycosphingolipids. The NPC1 protein is a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. NPC1 transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolyzed and released as free cholesterol. NPC1, in addition to FTO, MC4R, and PTER has recently been shown to be a new risk loci for early-onset and morbid adult obesity in European populations.

仅用于科研。不用于诊断过程。未经明确授权不得转售。