Invitrogen

NPC1 Monoclonal Antibody (8D10B6)

NPC1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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NPC1 Antibody (MA5-31807) in IHC (P)

Immunohistochemistry analysis of NPC1 in paraffin-embedded esophageal cancer tissue. Sample was incubated with NPC1 monoclonal antibody (Product # MA5-31807) using a dilution of 1:200-1:1000 followed by DAB staining.

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产品信息

MA5-31807

应用

建议稀释比

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免疫印迹 (WB)

1:500-1:2,000

免疫组化（石蜡） (IHC (P))

1:200-1:1,000

酶联免疫吸附实验 (ELISA)

1:10,000

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

8D10B6

抗原

Purified recombinant fragment of human NPC1 (AA: 34-174) expressed in E. coli.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein G

保存液

PBS

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2787430

产品详细信息

MA5-31807 has been tested in indirect ELISA.

靶标信息

Mutations in the Niemann-Pick disease type C1 (NPC1) gene result in a fatal progressive neurodegenerative disorder characterized by an abnormal sequestration of lipids including cholesterol and glycosphingolipids. The NPC1 protein is a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. NPC1 transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolyzed and released as free cholesterol. NPC1, in addition to FTO, MC4R, and PTER has recently been shown to be a new risk loci for early-onset and morbid adult obesity in European populations.

仅用于科研。不用于诊断过程。未经明确授权不得转售。