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产品信息
PA5-100293
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human NPHP3(Accession Q7Z494), corresponding to amino acid residues T1111-A1161.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2849807
产品详细信息
Antibody detects endogenous levels of total NPHP3.
靶标信息
Required for normal ciliary development and function. Inhibits disheveled-1-induced canonical Wnt-signaling activity and may also play a role in the control of non-canonical Wnt signaling which regulates planar cell polarity. Probably acts as a molecular switch between different Wnt signaling pathways. Required for proper convergent extension cell movements.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cilia and flagella associated protein 31; Meckel syndrome, type 7; Nephrocystin-3
基因别名: 3632410F03Rik; AI550417; C230078J01; CFAP31; D330020E01Rik; KIAA2000; MKS7; NPH3; NPHP3; pcy; RHPD; RHPD1; SLSN3
UniProt ID: (Human) Q7Z494, (Mouse) Q7TNH6
Entrez Gene ID: (Human) 27031, (Mouse) 74025
kidney development
heart looping
atrial septum development
lipid metabolic process
establishment or maintenance of cell polarity
determination of left/right symmetry
Wnt signaling pathway
extracellular matrix organization
lung development
regulation of cAMP metabolic process
determination of pancreatic left/right asymmetry
photoreceptor cell maintenance
maintenance of organ identity
convergent extension involved in gastrulation
cilium morphogenesis
kidney morphogenesis
determination of intestine left/right asymmetry
determination of stomach left/right asymmetry
determination of liver left/right asymmetry
ureter development
negative regulation of canonical Wnt signaling pathway
epithelial cilium movement involved in determination of left/right asymmetry
regulation of Wnt signaling pathway, planar cell polarity pathway
regulation of planar cell polarity pathway involved in neural tube closure
