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产品信息
MA5-20772
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
1F4
抗原
NR1D1 (NP_068370, 233 a.a. ~ 322 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2609240
产品详细信息
Peptide Sequence: SQCPLETSPT QHPTPGPMGP SPPPAPVPSP LVGFSQFPQQ LTPPRSPSPE PTVEDVISQV ARAHREIFTY AHDKLGSSPG NFNANHASG
靶标信息
This gene encodes a member of the nuclear hormone receptor family, specifically the NR1 subfamily of receptors. The encoded protein functions as a transcriptional repressor and may play a role in circadian rhythms and carbohydrate and lipid metabolism. Alternatively spliced transcript variants have been described.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BD73; EAR-1; nuclear receptor Rev-ErbA-alpha; Nuclear receptor subfamily 1 group D member 1; nuclear receptor subfamily 1, group D, member 1; Rev-erba; Rev-erbA-alpha; Rev-ErbAalpha; Reverbaalpha; V-erbA-related protein 1
基因别名: ear-1; EAR1; HREV; NR1D1; THRA1; THRAL
UniProt ID: (Human) P20393
Entrez Gene ID: (Human) 9572
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
core promoter sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription corepressor binding
steroid hormone receptor activity
transcription corepressor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
zinc ion binding
heme binding
transcription regulatory region DNA binding
C4 zinc finger nuclear receptor
DNA-binding transcription factor
zinc finger transcription factor
gene-specific transcriptional regulator
negative regulation of transcription from RNA polymerase II promoter
glycogen biosynthetic process
transcription initiation from RNA polymerase II promoter
circadian rhythm
proteasomal protein catabolic process
negative regulation of receptor biosynthetic process
regulation of lipid metabolic process
cell differentiation
intracellular receptor signaling pathway
circadian regulation of gene expression
negative regulation of toll-like receptor 4 signaling pathway
regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter
regulation of circadian rhythm
steroid hormone mediated signaling pathway
response to leptin
regulation of fat cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
circadian temperature homeostasis
regulation of insulin secretion involved in cellular response to glucose stimulus
regulation of type B pancreatic cell proliferation
positive regulation of bile acid biosynthetic process
cellular response to lipopolysaccharide
regulation of cholesterol homeostasis
positive regulation of cholesterol homeostasis
