Abnova

NR1D1 Monoclonal Antibody (2A5)

查看其他17个NR1D1抗体

产品信息

H00009572-M19

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-5 µg/mL

-

酶联免疫吸附实验 (ELISA)

10 µg/mL

-

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG2a, kappa

分类

Monoclonal

类型

Antibody

克隆号

2A5

抗原

NR1D1 (NP_068370, 233 a.a. approximately 322 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.4

内含物

no preservative

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

产品详细信息

Immunogen sequence: SQCPLETSPT QHPTPGPMGP SPPPAPVPSP LVGFSQFPQQ LTPPRSPSPE PTVEDVISQV ARAHREIFTY AHDKLGSSPG NFNANHASG

靶标信息

This gene encodes a member of the nuclear hormone receptor family, specifically the NR1 subfamily of receptors. The encoded protein functions as a transcriptional repressor and may play a role in circadian rhythms and carbohydrate and lipid metabolism. Alternatively spliced transcript variants have been described.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: BD73; EAR-1; nuclear receptor Rev-ErbA-alpha; Nuclear receptor subfamily 1 group D member 1; nuclear receptor subfamily 1, group D, member 1; Rev-erba; Rev-erbA-alpha; Rev-ErbAalpha; Reverbaalpha; V-erbA-related protein 1

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基因别名: ear-1; EAR1; HREV; NR1D1; THRA1; THRAL

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UniProt ID: (Human) P20393

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Entrez Gene ID: (Human) 9572

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RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding core promoter sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding transcription corepressor binding steroid hormone receptor activity transcription corepressor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding zinc ion binding heme binding transcription regulatory region DNA binding C4 zinc finger nuclear receptor DNA-binding transcription factor zinc finger transcription factor gene-specific transcriptional regulator

参与通路

negative regulation of transcription from RNA polymerase II promoter glycogen biosynthetic process transcription initiation from RNA polymerase II promoter circadian rhythm proteasomal protein catabolic process negative regulation of receptor biosynthetic process regulation of lipid metabolic process cell differentiation intracellular receptor signaling pathway circadian regulation of gene expression negative regulation of toll-like receptor 4 signaling pathway regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter regulation of circadian rhythm steroid hormone mediated signaling pathway response to leptin regulation of fat cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated circadian temperature homeostasis regulation of insulin secretion involved in cellular response to glucose stimulus regulation of type B pancreatic cell proliferation positive regulation of bile acid biosynthetic process cellular response to lipopolysaccharide regulation of cholesterol homeostasis positive regulation of cholesterol homeostasis