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NR1D1 Antibody (MA5-42757) in WB
Western blot analysis of NR1D1 in extracts of various cell lines. Samples were incubated with NR1D1 Monoclonal antibody (Product # MA5-42757) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
产品信息
MA5-42757
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
9I2H1
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 280-360 of human Rev-Erbα/NR1D1 (NP_0683701)
偶联物
形式
Liquid
浓度
1.04 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2911898
产品详细信息
Positive test controls include: HepG2, Mouse liver, Rat brain, Rat lung.
Immunogen sequence: SPEPTVEDVI SQVARAHREI FTYAHDKLGS SPGNFNANHA SGSPPATTPH RWENQGCPPA PNDNNTLAAQ RHNEALNGLR Q
靶标信息
This gene encodes a member of the nuclear hormone receptor family, specifically the NR1 subfamily of receptors. The encoded protein functions as a transcriptional repressor and may play a role in circadian rhythms and carbohydrate and lipid metabolism. Alternatively spliced transcript variants have been described.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BD73; EAR-1; nuclear receptor protein; nuclear receptor Rev-ErbA-alpha; Nuclear receptor subfamily 1 group D member 1; nuclear receptor subfamily 1, group D, member 1; orphan nuclear receptor; rev-erb alpha; Rev-erba; rev-erbA alpha; rev-erbA(alpha); Rev-erbA-alpha; Rev-ErbA-alpha protein; Rev-ErbAalpha; REV-ERBalpha; Reverbaalpha; V-erbA-related protein 1; V-erbA-related protein EAR-1
基因别名: A530070C09Rik; ear-1; EAR1; HREV; NR1D1; R75201; REV-ERBAALPHA; THRA1; THRAL
UniProt ID: (Human) P20393, (Rat) Q63503, (Mouse) Q3UV55
Entrez Gene ID: (Human) 9572, (Rat) 252917, (Mouse) 217166
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
core promoter sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription corepressor binding
steroid hormone receptor activity
transcription corepressor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
zinc ion binding
heme binding
transcription regulatory region DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
sequence-specific DNA binding
metal ion binding
C4 zinc finger nuclear receptor
DNA-binding transcription factor
zinc finger transcription factor
gene-specific transcriptional regulator
negative regulation of transcription from RNA polymerase II promoter
glycogen biosynthetic process
transcription initiation from RNA polymerase II promoter
circadian rhythm
proteasomal protein catabolic process
negative regulation of receptor biosynthetic process
regulation of lipid metabolic process
cell differentiation
intracellular receptor signaling pathway
circadian regulation of gene expression
negative regulation of toll-like receptor 4 signaling pathway
regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter
regulation of circadian rhythm
steroid hormone mediated signaling pathway
response to leptin
regulation of fat cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
circadian temperature homeostasis
regulation of insulin secretion involved in cellular response to glucose stimulus
regulation of type B pancreatic cell proliferation
positive regulation of bile acid biosynthetic process
cellular response to lipopolysaccharide
regulation of cholesterol homeostasis
positive regulation of cholesterol homeostasis
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
rhythmic process
