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产品信息
H00008856-B01P
产品规格
种属反应
Human,
Rat
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
NR1I2 (NP_003880.3, 1 a.a. approximately 434 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MEVRPKESWN HADFVHCEDT ESVPGKPSVN ADEEVGGPQI CRVCGDKATG YHFNVMTCEG CKGFFRRAMK RNARLRCPFR KGACEITRKT RRQCQACRLR KCLESGMKKE MIMSDEAVEE RRALIKRKKS ERTGTQPLGV QGLTEEQRMM IRELMDAQMK TFDTTFSHFK NFRLPGVLSS GCELPESLQA PSREEAAKWS QVRKDLCSLK VSLQLRGEDG SVWNYKPPAD SGGKEIFSLL PHMADMSTYM FKGIISFAKV ISYFRDLPIE DQISLLKGAA FELCQLRFNT VFNAETGTWE CGRLSYCLED TAGGFQQLLL EPMLKFHYML KKLQLHEEEY VLMQAISLFS PDRPGVLQHR VVDQLQEQFA ITLKSYIECN RPQPAHRFLF LKIMAMLTEL RSINAQHTQR LLRIQDIHPF ATPLMQELFG ITGS
靶标信息
This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Nuclear receptor subfamily 1 group I member 2; nuclear receptor subfamily 1, group 1, member 2; nuclear receptor subfamily 1, group I, member 2; ONR 1; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; PAR 1; PAR 2; PAR q; pregnane X nuclear receptor variant 2; Pregnane X receptor; pregnane X receptor (nuclear receptor sub family 1, group I, member 2); Steroid and xenobiotic receptor; SXR
基因别名: BXR; NR1I2; ONR1; PAR; PAR1; PAR2; PARq; PRR; PXR; SAR; SXR
UniProt ID: (Human) O75469, (Rat) Q9R1A7
Entrez Gene ID: (Human) 8856, (Rat) 84385
RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
steroid hormone receptor activity
transcription coactivator activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
drug binding
zinc ion binding
transcription, DNA-templated
xenobiotic metabolic process
positive regulation of gene expression
intracellular receptor signaling pathway
exogenous drug catabolic process
xenobiotic transport
steroid hormone mediated signaling pathway
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
drug export
transcription initiation from RNA polymerase II promoter
signal transduction
steroid metabolic process
