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产品信息
H00004929-D01P
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
NR4A2 (NP_006177.1, 1 a.a. approximately 598 a.a) full-length human protein.
偶联物
Unconjugated
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: MPCVQAQYGS SPQGASPASQ SYSYHSSGEY SSDFLTPEFV KFSMDLTNTE ITATTSLPSF STFMDNYSTG YDVKPPCLYQ MPLSGQQSSI KVEDIQMHNY QQHSHLPPQS EEMMPHSGSV YYKPSSPPTP TTPGFQVQHS PMWDDPGSLH NFHQNYVATT HMIEQRKTPV SRLSLFSFKQ SPPGTPVSSC QMRFDGPLHV PMNPEPAGSH HVVDGQTFAV PNPIRKPASM GFPGLQIGHA SQLLDTQVPS PPSRGSPSNE GLCAVCGDNA ACQHYGVRTC EGCKGFFKRT VQKNAKYVCL ANKNCPVDKR RRNRCQYCRF QKCLAVGMVK EVVRTDSLKG RRGRLPSKPK SPQEPSPPSP PVSLISALVR AHVDSNPAMT SLDYSRFQAN PDYQMSGDDT QHIQQFYDLL TGSMEIIRGW AEKIPGFADL PKADQDLLFE SAFLELFVLR LAYRSNPVEG KLIFCNGVVL HRLQCVRGFG EWIDSIVEFS SNLQNMNIDI SAFSCIAALA MVTERHGLKE PKRVEELQNK IVNCLKDHVT FNNGGLNRPN YLSKLLGKLP ELRTLCTQGL QRIFYLKLED LVPPPAIIDK LFLDTLPF
靶标信息
The Nuclear receptor related 1 protein (Nurr1) also known as NR4A2 (nuclear receptor subfamily 4, group A, member 2) is a protein that in humans is encoded by the NR4A2 gene. NURR1 is a member of the nuclear receptor family of intracellular transcription factors.Nurr1 plays a key role in the maintenance of the dopaminergic system of the brain. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson's disease, schizophrenia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Four transcript variants encoding four distinct isoforms have been identified for this gene. Additional alternate splice variants may exist, but their full-length nature has not been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: HZF3; Immediate-early response protein NOT; intermediate-early receptor protein; NGFI-B; NGFI-B beta; NGFI-B/nur77 beta-type transcription factor homolog; nuclear receptor related 1; Nuclear receptor subfamily 4 group A member 2; nuclear receptor subfamily 4, group A, member 2; nur related protein-1, human homolog of; orphan nuclear receptor NR4A2; Orphan nuclear receptor NURR1; T-cell nuclear receptor NOT; transcriptionally inducible nuclear receptor related 1; Transcriptionally-inducible nuclear receptor
基因别名: HZF-3; NOT; NR4A2; NURR1; RNR1; TINUR
UniProt ID: (Human) P43354
Entrez Gene ID: (Human) 4929
RNA polymerase II core promoter sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
steroid hormone receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
beta-catenin binding
zinc ion binding
glucocorticoid receptor binding
protein homodimerization activity
retinoid X receptor binding
protein heterodimerization activity
C4 zinc finger nuclear receptor
negative regulation of transcription from RNA polymerase II promoter
response to hypoxia
neuron migration
response to amphetamine
transcription, DNA-templated
transcription initiation from RNA polymerase II promoter
signal transduction
adult locomotory behavior
post-embryonic development
central nervous system projection neuron axonogenesis
habenula development
intracellular receptor signaling pathway
cellular response to extracellular stimulus
cellular response to oxidative stress
regulation of dopamine metabolic process
dopamine biosynthetic process
neuron maturation
positive regulation of catalytic activity
steroid hormone mediated signaling pathway
negative regulation of neuron apoptotic process
regulation of respiratory gaseous exchange
fat cell differentiation
positive regulation of transcription from RNA polymerase II promoter
general adaptation syndrome
canonical Wnt signaling pathway
cellular response to corticotropin-releasing hormone stimulus
dopaminergic neuron differentiation
midbrain dopaminergic neuron differentiation
negative regulation of apoptotic signaling pathway
