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产品信息
PA5-143112
产品规格
种属反应
Human,
Pig
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide with sequence C-TDYDRSPFVTSPIS.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2933751
产品详细信息
Additional Information: This antibody is expected to recognize both reported isoforms (NP_995582.1; NP_003813.1).
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
靶标信息
Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Alpha-1-fetoprotein transcription factor; B1-binding factor; b1-binding factor, hepatocyte transcription factor which activates enhancer II of hepatitis B virus; CYP7A promoter-binding factor; fetoprotein-alpha 1 (AFP) transcription factor; FTZ F1; FTZ F1beta; hB1F; hB1F 2; Hepatocytic transcription factor; hepatocytic transcription factor hB1F-3; live; liver nuclear receptor homolog-1 variant 2; Liver receptor homolog 1; LRH-1; Nuclear receptor subfamily 5 group A member 2; nuclear receptor subfamily 5, group A, member 2
基因别名: B1F; B1F2; CPF; FTF; FTZ-F1; FTZ-F1beta; hB1F-2; LRH-1; LRH1; NR5A2
UniProt ID: (Human) O00482
Entrez Gene ID: (Pig) 100523688, (Human) 2494
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
steroid hormone receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
phospholipid binding
zinc ion binding
sequence-specific DNA binding
transcription regulatory region DNA binding
C4 zinc finger nuclear receptor
regulation of transcription, DNA-templated
transcription initiation from RNA polymerase II promoter
bile acid metabolic process
hormone-mediated signaling pathway
embryo development
tissue development
intracellular receptor signaling pathway
epithelial cell differentiation
regulation of cell proliferation
homeostatic process
cholesterol homeostasis
steroid hormone mediated signaling pathway
positive regulation of viral genome replication
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
pancreas morphogenesis
