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产品信息
PA5-89359
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 300-541 of human NR5A2 (NP_9955821)
偶联物
形式
Liquid
浓度
0.79 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2805517
产品详细信息
Immunogen sequence: SIPHLILELL KCEPDEPQVQ AKIMAYLQQE QANRSKHEKL STFGLMCKMA DQTLFSIVEW ARSSIFFREL KVDDQMKLLQ NCWSELLILD HIYRQVVHGK EGSIFLVTGQ QVDYSIIASQ AGATLNNLMS HAQELVAKLR SLQFDQREFV CLKFLVLFSL DVKNLENFQL VEGVQEQVNA ALLDYTMCNY PQQTEKFGQL LLRLPEIRAI SMQAEEYLYY KHLNGDVPYN NLLIEMLHAK RA
Positive Samples: Mouse liver; Cellular Location: Nucleus
靶标信息
Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Alpha-1-fetoprotein transcription factor; B1-binding factor; b1-binding factor, hepatocyte transcription factor which activates enhancer II of hepatitis B virus; CYP7A promoter-binding factor; fetoprotein transcription factor; fetoprotein-alpha 1 (AFP) transcription factor; FTZ F1; FTZ F1beta; FTZ-F1 beta; FTZ-F1 beta2 protein; hB1F; hB1F 2; Hepatocytic transcription factor; hepatocytic transcription factor hB1F-3; live; liver nuclear receptor homolog-1 variant 2; Liver receptor homolog 1; LRH-1; Nuclear receptor subfamily 5 group A member 2; nuclear receptor subfamily 5, group A, member 2
基因别名: AU020803; B1F; B1F2; CPF; D1Ertd308e; FTF; FTZ-F1; FTZ-F1beta; hB1F-2; LRH-1; LRH1; NR5A2; UF2-H3B
UniProt ID: (Human) O00482, (Rat) Q9QWM1, (Mouse) P45448
Entrez Gene ID: (Human) 2494, (Rat) 60349, (Mouse) 26424
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
steroid hormone receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
phospholipid binding
zinc ion binding
sequence-specific DNA binding
transcription regulatory region DNA binding
double-stranded DNA binding
lipid binding
metal ion binding
C4 zinc finger nuclear receptor
regulation of transcription, DNA-templated
transcription initiation from RNA polymerase II promoter
bile acid metabolic process
hormone-mediated signaling pathway
embryo development
tissue development
intracellular receptor signaling pathway
epithelial cell differentiation
regulation of cell proliferation
homeostatic process
cholesterol homeostasis
steroid hormone mediated signaling pathway
positive regulation of viral genome replication
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
pancreas morphogenesis
transcription, DNA-templated
transcription from RNA polymerase II promoter
regulation of transcription from RNA polymerase II promoter
