Invitrogen

NTF3 Polyclonal Antibody

查看其他18个NTF3抗体

产品信息

PA1-18384

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-10 µg/mL

-

酶联免疫吸附实验 (ELISA)

1-10 µg/mL

-

产品规格

种属反应

Chicken, Human, Rat

宿主/亚型

Sheep / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide corresponding to residues Y(139) A E H K S H R G E Y(149) of human, mouse and rat NT3.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS

内含物

no preservative

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_1077202

产品详细信息

Reconstitute in 50 µL of sterile water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20 °C for a higher stability, and at 4 °C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.

靶标信息

The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: HDNF; Nerve growth factor 2; Neurotrophic factor; Neurotrophin-3; neurotrophin-3 (HDNF/NT-3); NGF-2; NT-3

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基因别名: HDNF; neurotrophin-3; NGF-2; NGF2; NT-3; NT3; Ntf-3; NTF3

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UniProt ID: (Chicken) P25433, (Human) P20783, (Rat) P18280

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Entrez Gene ID: (Chicken) 428099, (Human) 4908, (Rat) 81737

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nerve growth factor receptor binding growth factor activity receptor binding neurotrophin p75 receptor binding protein binding chemoattractant activity nerve growth factor binding neurotrophic factor

参与通路

transmembrane receptor protein tyrosine kinase signaling pathway peripheral nervous system development memory nerve development positive regulation of peptidyl-serine phosphorylation nerve growth factor signaling pathway negative regulation of neuron apoptotic process regulation of neuron differentiation neuron projection morphogenesis modulation of synaptic transmission activation of MAPK activity positive regulation of receptor internalization signal transduction cell-cell signaling nervous system development positive regulation of cell proliferation positive regulation of cell migration activation of protein kinase B activity myelination regulation of apoptotic process positive regulation of glial cell differentiation positive regulation of peptidyl-tyrosine phosphorylation negative regulation of peptidyl-tyrosine phosphorylation positive chemotaxis induction of positive chemotaxis activation of GTPase activity positive regulation of actin cytoskeleton reorganization neuromuscular synaptic transmission glial cell fate determination axon guidance brain development epidermis development mechanoreceptor differentiation regulation of neuron apoptotic process positive regulation of transcription from RNA polymerase II promoter enteric nervous system development neuron development generation of neurons smooth muscle cell differentiation