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Immunogen sequence: MALRACGLIIF RRCLIPKVDN NAIEFLLLQA SDGIHHWTPP KGHVEPGEDD LETALR
Highest antigen sequence identity to the following orthologs - mouse 89%, rat 91%.
This gene encodes a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NUDIX hydrolase family. The gene product possesses a modification of the MutT sequence motif found in certain nucleotide pyrophosphatases. The enzyme asymmetrically hydrolyzes Ap4A to yield AMP and ATP and is responsible for maintaining the intracellular level of the dinucleotide Ap4A, the function of which has yet to be established. This gene may be a candidate tumor suppressor gene. Alternative splicing has been observed at this locus and three transcript variants, all encoding the same protein, have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Ap4A hydrolase; Ap4A hydrolase 1; Ap4Aase; bis(5'-nucleosyl)-tetraphosphatase (asymmetrical); Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]; Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase; diadenosine 5',5''-P1,P4-tetraphosphate pyrophosphohydrolase; diadenosine tetraphosphatase; MGC10404; Nucleoside diphosphate-linked moiety X motif 2; nudix (nucleoside diphosphate linked moiety X)-type motif 2; Nudix motif 2
基因别名: APAH1; NUDT2
UniProt ID: (Human) P50583
Entrez Gene ID: (Human) 318