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This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
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This antibody is predicted to react with Monkey, Horse, Pig.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Protein NUMB homolog is an evolutionarily conserved protein that controls the differentiation of neuronal progenitor cells. Recent studies have revealed that NUMB functions in clathrin-dependent endocytosis by binding to the AP-2 complex. NUMB is also expressed in postmitotic neurons and plays a role in axonal growth. Neural cells expressing Numb isoforms with short phosphotyrosine-binding (SPTB) domain undergo extensive neurite outgrowth, an effect that can be blocked by voltage-gated Ca2+ channel (VGCC) inhibitor or by Ca2+ chelator.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: h-Numb; m-numb; mnb; numb homolog; Protein numb homolog; Protein S171
基因别名: c14_5527; C14orf41; NUMB; S171
UniProt ID: (Human) P49757
Entrez Gene ID: (Human) 8650